1m4z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1m4z.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1m4z.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1m4z| PDB=1m4z | SCENE= }}
{{STRUCTURE_1m4z| PDB=1m4z | SCENE= }}
-
'''Crystal structure of the N-terminal BAH domain of Orc1p'''
+
===Crystal structure of the N-terminal BAH domain of Orc1p===
-
==Overview==
+
<!--
-
The N-terminal domain of the largest subunit of the Saccharomyces cerevisiae origin recognition complex (Orc1p) functions in transcriptional silencing and contains a bromo-adjacent homology (BAH) domain found in some chromatin-associated proteins including Sir3p. The 2.2 A crystal structure of the N-terminal domain of Orc1p revealed a BAH core and a non-conserved helical sub-domain. Mutational analyses demonstrated that the helical sub-domain was necessary and sufficient to bind Sir1p, and critical for targeting Sir1p primarily to the cis-acting E silencers at the HMR and HML silent chromatin domains. In the absence of the BAH domain, approximately 14-20% of cells in a population were silenced at the HML locus. Moreover, the distributions of the Sir2p, Sir3p and Sir4p proteins, while normal, were at levels lower than found in wild-type cells. Thus, in the absence of the Orc1p BAH domain, HML resembled silencing of genes adjacent to telomeres. These data are consistent with the view that the Orc1p-Sir1p interaction at the E silencers ensures stable inheritance of pre-established Sir2p, Sir3p and Sir4p complexes at the silent mating type loci.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12198162}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12198162 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12198162}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Dna replication]]
[[Category: Dna replication]]
[[Category: Transcriptional silencing]]
[[Category: Transcriptional silencing]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:38:14 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:13:16 2008''

Revision as of 20:13, 2 July 2008

Image:1m4z.png

Template:STRUCTURE 1m4z

Crystal structure of the N-terminal BAH domain of Orc1p

Template:ABSTRACT PUBMED 12198162

About this Structure

1M4Z is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure and function of the BAH-containing domain of Orc1p in epigenetic silencing., Zhang Z, Hayashi MK, Merkel O, Stillman B, Xu RM, EMBO J. 2002 Sep 2;21(17):4600-11. PMID:12198162

Page seeded by OCA on Wed Jul 2 23:13:16 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1m4z"
Personal tools