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1m51

From Proteopedia

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[[Image:1m51.gif|left|200px]]
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{{STRUCTURE_1m51| PDB=1m51 | SCENE= }}
{{STRUCTURE_1m51| PDB=1m51 | SCENE= }}
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'''PEPCK complex with a GTP-competitive inhibitor'''
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===PEPCK complex with a GTP-competitive inhibitor===
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==Overview==
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The analysis of the X-ray structures of two xanthine inhibitors bound to PEPCK and a comparison to the X-ray structure of GTP bound to PEPCK are reported. The SAR at N-1, N-7 and developing SAR at C-8 are consistent with information gained from the X-ray structures of compounds 1 and 2 bound to PEPCK. Representative N-3 modifications of compound 2 that led to the discovery of 3-cyclopropylmethyl and its carboxy analogue as optimal N-3 groups are presented.
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The line below this paragraph, {{ABSTRACT_PUBMED_14552798}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14552798 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14552798}}
==Disease==
==Disease==
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[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Xanthine]]
[[Category: Xanthine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:38:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:13:34 2008''

Revision as of 20:13, 2 July 2008

Image:1m51.png

Template:STRUCTURE 1m51

Contents

PEPCK complex with a GTP-competitive inhibitor

Template:ABSTRACT PUBMED 14552798

Disease

Known disease associated with this structure: Hypoglycemia due to PCK1 deficiency (1) OMIM:[261680]

About this Structure

1M51 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-dibenzylxanthines., Foley LH, Wang P, Dunten P, Ramsey G, Gubler ML, Wertheimer SJ, Bioorg Med Chem Lett. 2003 Nov 3;13(21):3871-4. PMID:14552798

Page seeded by OCA on Wed Jul 2 23:13:34 2008

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