1m55

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1m55.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1m55.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1m55| PDB=1m55 | SCENE= }}
{{STRUCTURE_1m55| PDB=1m55 | SCENE= }}
-
'''Catalytic domain of the Adeno Associated Virus type 5 Rep protein'''
+
===Catalytic domain of the Adeno Associated Virus type 5 Rep protein===
-
==Overview==
+
<!--
-
Adeno-associated virus (AAV), unique among animal viruses in its ability to integrate into a specific chromosomal location, is a promising vector for human gene therapy. AAV Replication (Rep) protein is essential for viral replication and integration, and its amino terminal domain possesses site-specific DNA binding and endonuclease activities required for replication initiation and integration. This domain displays a novel endonuclease fold and demonstrates an unexpected structural relationship to other viral origin binding proteins such as the papillomavirus E1 protein and the SV40 T antigen. The active site, located at the bottom of a positively charged cleft, is formed by the spatial convergence of a divalent metal ion and two conserved sequence motifs that define the rolling circle replication superfamily.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12191478}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12191478 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12191478}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Rep]]
[[Category: Rep]]
[[Category: Rolling circle replication]]
[[Category: Rolling circle replication]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:38:39 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:13:57 2008''

Revision as of 20:13, 2 July 2008

Image:1m55.png

Template:STRUCTURE 1m55

Catalytic domain of the Adeno Associated Virus type 5 Rep protein

Template:ABSTRACT PUBMED 12191478

About this Structure

1M55 is a Single protein structure of sequence from Adeno-associated virus - 5. Full crystallographic information is available from OCA.

Reference

Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep., Hickman AB, Ronning DR, Kotin RM, Dyda F, Mol Cell. 2002 Aug;10(2):327-37. PMID:12191478

Page seeded by OCA on Wed Jul 2 23:13:57 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1m55"
Personal tools