1m4r
From Proteopedia
(New page: 200px<br /> <applet load="1m4r" size="450" color="white" frame="true" align="right" spinBox="true" caption="1m4r, resolution 2.00Å" /> '''CRYSTAL STRUCTURE O...) |
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| - | [[Image:1m4r. | + | [[Image:1m4r.jpg|left|200px]]<br /><applet load="1m4r" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1m4r" size=" | + | |
caption="1m4r, resolution 2.00Å" /> | caption="1m4r, resolution 2.00Å" /> | ||
'''CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22'''<br /> | '''CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1M4R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1M4R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4R OCA]. |
==Reference== | ==Reference== | ||
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[[Category: interleukin-22 (il-22)]] | [[Category: interleukin-22 (il-22)]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:22:03 2008'' |
Revision as of 14:22, 15 February 2008
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CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22
Overview
Interleukin-22 (IL-10-related T cell-derived inducible, factor/IL-TIF/IL-22) is a novel cytokine belonging to the IL-10 family., Recombinant human IL-22 (hIL-22) was found to activate the signal, transducers and activators of transcription factors 1 and 3 as well as, acute phase reactants in several hepatoma cell lines, suggesting its, involvement in the inflammatory response. The crystallographic structure, of recombinant hIL-22 has been solved at 2.0 A resolution using the SIRAS, method. Contrary to IL-10, the hIL-22 dimer does not present an, interpenetration of the secondary-structure elements belonging to the two, distinct polypeptide chains but results from interface interactions, between monomers. Structural differences between these two cytokines, revealed by the crystallographic studies, clearly indicate that, while a, homodimer of IL-10 is required for signaling, hIL-22 most probably, interacts with its receptor as a monomer.
About this Structure
1M4R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of recombinant human interleukin-22., Nagem RA, Colau D, Dumoutier L, Renauld JC, Ogata C, Polikarpov I, Structure. 2002 Aug;10(8):1051-62. PMID:12176383
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