1m5n

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[[Image:1m5n.gif|left|200px]]
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{{Seed}}
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[[Image:1m5n.png|left|200px]]
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{{STRUCTURE_1m5n| PDB=1m5n | SCENE= }}
{{STRUCTURE_1m5n| PDB=1m5n | SCENE= }}
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'''Crystal structure of HEAT repeats (1-11) of importin b bound to the non-classical NLS(67-94) of PTHrP'''
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===Crystal structure of HEAT repeats (1-11) of importin b bound to the non-classical NLS(67-94) of PTHrP===
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==Overview==
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Nuclear import of proteins containing a classical nuclear localization signal (NLS) involves NLS recognition by importin alpha, which associates with importin beta via the IBB domain. Other proteins, including parathyroid hormone-related protein (PTHrP), are imported into the nucleus by direct interaction with importin beta. We solved the crystal structure of a fragment of importin beta-1 (1-485) bound to the nonclassical NLS of PTHrP. The structure reveals a second extended cargo binding site on importin beta distinct from the IBB domain binding site. Using a permeabilized cell import assay we demonstrate that importin beta (1-485) can import PTHrP-coupled cargo in a Ran-dependent manner. We propose that this region contains a prototypical nuclear import receptor domain, which could have evolved into the modern importin beta superfamily.
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The line below this paragraph, {{ABSTRACT_PUBMED_12504010}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12504010 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12504010}}
==About this Structure==
==About this Structure==
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[[Category: All helical protein]]
[[Category: All helical protein]]
[[Category: Heat repeat]]
[[Category: Heat repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:39:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:15:52 2008''

Revision as of 20:15, 2 July 2008

Image:1m5n.png

Template:STRUCTURE 1m5n

Crystal structure of HEAT repeats (1-11) of importin b bound to the non-classical NLS(67-94) of PTHrP

Template:ABSTRACT PUBMED 12504010

About this Structure

1M5N is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta., Cingolani G, Bednenko J, Gillespie MT, Gerace L, Mol Cell. 2002 Dec;10(6):1345-53. PMID:12504010

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