8ka3

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'''Unreleased structure'''
 
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The entry 8ka3 is ON HOLD until Paper Publication
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==Arabidopsis AP endonuclease APR complex with 22bp THF-containing DNA==
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<StructureSection load='8ka3' size='340' side='right'caption='[[8ka3]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ka3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8KA3 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ka3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ka3 OCA], [https://pdbe.org/8ka3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ka3 RCSB], [https://www.ebi.ac.uk/pdbsum/8ka3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ka3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARP_ARATH ARP_ARATH] Repairs oxidative DNA damages, seems also to act as a redox factor (PubMed:7512729). Is multifunctional and may be involved both in DNA repair and in the regulation of transcription (PubMed:7512729). Exhibits apurinic/apyrimidinic (AP) endonuclease activity (PubMed:25569774, PubMed:21781197, PubMed:25228464). Catalyzes the conversion of 3'-phosphor-alpha,beta-unsaturated aldehyde (3'-PUA) to 3'-OH (PubMed:25228464). May be involved in base excision repair in chloroplasts (PubMed:19372224). According to a report, has a significant in vitro 3'-phosphatase activity (PubMed:25228464). According to another report, has no in vitro 3'-phosphatase activity (PubMed:25569774). Has a strong non-specific affinity to DNA (PubMed:25228464).<ref>PMID:19372224</ref> <ref>PMID:21781197</ref> <ref>PMID:25228464</ref> <ref>PMID:25569774</ref> <ref>PMID:7512729</ref> <ref>PMID:19172180</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arabidopsis thaliana]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Guo WT]]
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[[Category: Wu BX]]

Revision as of 08:55, 21 February 2024

Arabidopsis AP endonuclease APR complex with 22bp THF-containing DNA

PDB ID 8ka3

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OCA

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