1m60

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[[Image:1m60.gif|left|200px]]
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{{STRUCTURE_1m60| PDB=1m60 | SCENE= }}
{{STRUCTURE_1m60| PDB=1m60 | SCENE= }}
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'''Solution Structure of Zinc-substituted cytochrome c'''
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===Solution Structure of Zinc-substituted cytochrome c===
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==Overview==
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Zinc-substituted cytochrome c has been widely used in studies of protein-protein interactions and photo-induced electron transfer reactions between proteins. However, the coordination geometry of zinc in zinc-substituted cyt c has not yet been determined; two different opinions about the coordination have been reached. Here the solution structures of zinc-substituted cytochrome c that might be five-coordinated and six-coordinated have been refined separately by using (1)H NMR spectroscopy, and the zinc coordination geometry was determined just by NOE distance constraints. Structural analysis of the energy-minimized average solution structures of both the pentacoordinated and hexacoordinated geometries indicate that that zinc in zinc-substituted cyt c should be bound to both His18 and Met80, which means that the zinc is six-coordinated. RMSD values of the family of 25 six-coordinated structures from the average structure are 0.66+/-0.13 A and 1.09+/-0.16 A for the backbone and all heavy atoms, respectively. A statistical analysis of the structure indicates its satisfactory quality. Comparison of the solution structure of the six-coordinated energy-minimized average structure of zinc-substituted cytochrome c with the solution structure of reduced cytochrome c reveals that for the overall folding the secondary structure elements are very close. The availability of the structure provides for a better understanding of the protein-protein complex and for electron transfer processes between Zn cyt c and other metalloproteins.
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{{ABSTRACT_PUBMED_12761660}}
==About this Structure==
==About this Structure==
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1M60 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M60 OCA].
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1M60 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M60 OCA].
==Reference==
==Reference==
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[[Category: Yao, Y.]]
[[Category: Yao, Y.]]
[[Category: Six-coordinated zinc cyt c]]
[[Category: Six-coordinated zinc cyt c]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:17:21 2008''

Revision as of 20:17, 2 July 2008

Image:1m60.png

Template:STRUCTURE 1m60

Solution Structure of Zinc-substituted cytochrome c

Template:ABSTRACT PUBMED 12761660

About this Structure

1M60 is a Single protein structure of sequence from Equus caballus. Full experimental information is available from OCA.

Reference

Structural analysis of zinc-substituted cytochrome c., Qian C, Yao Y, Tong Y, Wang J, Tang W, J Biol Inorg Chem. 2003 Apr;8(4):394-400. Epub 2002 Dec 14. PMID:12761660

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