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1m62

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[[Image:1m62.gif|left|200px]]
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{{STRUCTURE_1m62| PDB=1m62 | SCENE= }}
{{STRUCTURE_1m62| PDB=1m62 | SCENE= }}
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'''Solution structure of the BAG domain from BAG4/SODD'''
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===Solution structure of the BAG domain from BAG4/SODD===
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==Overview==
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BAG (Bcl-2-associated athanogene) proteins are molecular chaperone regulators that affect diverse cellular pathways. All members share a conserved motif, called the BAG domain (BD), which binds to Hsp70/Hsc70 family proteins and modulates their activity. We have determined the solution structure of BD from BAG4/SODD (silencer of death domains) by multidimensional nuclear magnetic resonance methods and compared it to the corresponding domain in BAG1 (Briknarova, K., Takayama, S., Brive, L., Havert, M. L., Knee, D. A., Velasco, J., Homma, S., Cabezas, E., Stuart, J., Hoyt, D. W., Satterthwait, A. C., Llinas, M., Reed, J. C., and Ely, K. R. (2001) Nat. Struct. Biol. 8, 349-352). The difference between BDs from these two BAG proteins is striking, and the structural comparison defines two subfamilies of mammalian BD-containing proteins. One subfamily includes the closely related BAG3, BAG4, and BAG5 proteins, and the other is represented by BAG1, which contains a structurally and evolutionarily distinct BD. BDs from both BAG1 and BAG4 are three-helix bundles; however, in BAG4, each helix in this bundle is three to four turns shorter than its counterpart in BAG1, which reduces the length of the domain by one-third. BAG4 BD thus represents a prototype of the minimal functional fragment that is capable of binding to Hsc70 and modulating its chaperone activity.
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(as it appears on PubMed at http://www.pubmed.gov), where 12058034 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12058034}}
==About this Structure==
==About this Structure==
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1M62 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M62 OCA].
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1M62 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M62 OCA].
==Reference==
==Reference==
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[[Category: Silencer of death domain]]
[[Category: Silencer of death domain]]
[[Category: Sodd]]
[[Category: Sodd]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:40:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:17:44 2008''

Revision as of 20:17, 2 July 2008

Image:1m62.png

Template:STRUCTURE 1m62

Solution structure of the BAG domain from BAG4/SODD

Template:ABSTRACT PUBMED 12058034

About this Structure

1M62 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

BAG4/SODD protein contains a short BAG domain., Briknarova K, Takayama S, Homma S, Baker K, Cabezas E, Hoyt DW, Li Z, Satterthwait AC, Ely KR, J Biol Chem. 2002 Aug 23;277(34):31172-8. Epub 2002 Jun 10. PMID:12058034

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