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8tv4

From Proteopedia

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m (Protected "8tv4" [edit=sysop:move=sysop])
Current revision (06:28, 6 September 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8tv4 is ON HOLD
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==NMR structure of temporin L in solution==
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<StructureSection load='8tv4' size='340' side='right'caption='[[8tv4]]' scene=''>
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Authors: McShan, A.C., Jia, R., Halim, M.A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8tv4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rana_temporaria Rana temporaria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TV4 FirstGlance]. <br>
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Description: NMR structure of temporin L in solution
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tv4 OCA], [https://pdbe.org/8tv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tv4 RCSB], [https://www.ebi.ac.uk/pdbsum/8tv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tv4 ProSAT]</span></td></tr>
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[[Category: Halim, M.A]]
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</table>
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[[Category: Mcshan, A.C]]
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== Function ==
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[[Category: Jia, R]]
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[https://www.uniprot.org/uniprot/TPL_RANTE TPL_RANTE] Amphipathic alpha-helical antimicrobial peptide with potent activity against both Gram-negative and Gram-positive bacteria, and against fungi (PubMed:9022710, PubMed:12133008, PubMed:16867990, PubMed:18370376, PubMed:31358802). Mainly acts by causing perturbation of bilayer integrity of both neutral and negatively charged membranes, probably by forming pore-like openings (PubMed:12133008, PubMed:31358802). Also displays anti-leishmania activity by damaging parasite membrane (By similarity). Shows hemolytic activity (PubMed:12133008). Also shows cytotoxicity against cancer cell lines (PubMed:12133008). Strongly binds to lipopolysaccharides (LPS) and its lipid A portion (PubMed:16801429) (Probable). Improves temporin-A and temporin-B activities by preventing their homo-oligomerization in LPS (PubMed:16867990, PubMed:21586570). In vivo, its simultaneous administration with beta-lactam antibiotics produces the highest antimicrobial activities and the strongest reduction in plasma LPS and TNF-alpha levels, resulting in the highest survival rates in rat models of septic shock (PubMed:16801429).[UniProtKB:P56917][UniProtKB:P79874]<ref>PMID:12133008</ref> <ref>PMID:16801429</ref> <ref>PMID:16867990</ref> <ref>PMID:18370376</ref> <ref>PMID:21586570</ref> <ref>PMID:31358802</ref> <ref>PMID:9022710</ref> <ref>PMID:21586570</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Rana temporaria]]
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[[Category: Halim MA]]
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[[Category: Jia R]]
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[[Category: McShan AC]]

Current revision

NMR structure of temporin L in solution

PDB ID 8tv4

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