1m6b
From Proteopedia
(New page: 200px<br /> <applet load="1m6b" size="450" color="white" frame="true" align="right" spinBox="true" caption="1m6b, resolution 2.60Å" /> '''Structure of the HE...) |
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| - | [[Image:1m6b. | + | [[Image:1m6b.jpg|left|200px]]<br /><applet load="1m6b" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1m6b, resolution 2.60Å" /> | caption="1m6b, resolution 2.60Å" /> | ||
'''Structure of the HER3 (ERBB3) Extracellular Domain'''<br /> | '''Structure of the HER3 (ERBB3) Extracellular Domain'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1M6B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG, NDG and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http:// | + | 1M6B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=NDG:'>NDG</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M6B OCA]. |
==Reference== | ==Reference== | ||
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[[Category: tyrosine kinase; cell surface receptor; immunity]] | [[Category: tyrosine kinase; cell surface receptor; immunity]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:22:11 2008'' |
Revision as of 14:22, 15 February 2008
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Structure of the HER3 (ERBB3) Extracellular Domain
Contents |
Overview
We have determined the 2.6 angstrom crystal structure of the entire, extracellular region of human HER3 (ErbB3), a member of the epidermal, growth factor receptor (EGFR) family. The structure consists of four, domains with structural homology to domains found in the type I, insulin-like growth factor receptor. The HER3 structure reveals a contact, between domains II and IV that constrains the relative orientations of, ligand-binding domains and provides a structural basis for understanding, both multiple-affinity forms of EGFRs and conformational changes induced, in the receptor by ligand binding during signaling. These results also, suggest new therapeutic approaches to modulating the behavior of members, of the EGFR family.
Disease
Known disease associated with this structure: Lethal congenital contractural syndrome 2 OMIM:[190151]
About this Structure
1M6B is a Single protein structure of sequence from Homo sapiens with , and as ligands. Active as Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 Full crystallographic information is available from OCA.
Reference
Structure of the extracellular region of HER3 reveals an interdomain tether., Cho HS, Leahy DJ, Science. 2002 Aug 23;297(5585):1330-3. Epub 2002 Aug 1. PMID:12154198
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