1m7b
From Proteopedia
(New page: 200px<br /> <applet load="1m7b" size="450" color="white" frame="true" align="right" spinBox="true" caption="1m7b, resolution 2.00Å" /> '''Crystal structure o...) |
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caption="1m7b, resolution 2.00Å" /> | caption="1m7b, resolution 2.00Å" /> | ||
'''Crystal structure of Rnd3/RhoE: functional implications'''<br /> | '''Crystal structure of Rnd3/RhoE: functional implications'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1M7B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG and GTP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1M7B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=GTP:'>GTP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M7B OCA]. |
==Reference== | ==Reference== | ||
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[[Category: small gtpase]] | [[Category: small gtpase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:22:23 2008'' |
Revision as of 14:22, 15 February 2008
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Crystal structure of Rnd3/RhoE: functional implications
Overview
The Rnd proteins constitute an exceptional subfamily within the Rho GTPase, family. They possess extended chains at both termini and four prominent, amino acid deviations causing GTPase deficiency. Herein, we report the, crystal structure of the Rnd3/RhoE G-domain (amino acids 19-200) at 2.0 A, resolution. This is the first GTP-structure of a Rho family member which, reveals a similar fold but striking differences from RhoA concerning (i), GTPase center, (ii) charge distribution at several surface areas, (iii), C3-transferase binding site and (iv) interacting interfaces towards RhoA, regulators and effectors.
About this Structure
1M7B is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of Rnd3/RhoE: functional implications., Fiegen D, Blumenstein L, Stege P, Vetter IR, Ahmadian MR, FEBS Lett. 2002 Aug 14;525(1-3):100-4. PMID:12163169
Page seeded by OCA on Fri Feb 15 16:22:23 2008
Categories: Homo sapiens | Single protein | Ahmadian, M.R. | Blumenstein, L. | Fiegen, D. | Stege, P. | Vetter, I.R. | GTP | MG | Small gtpase
