1m7q

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{{STRUCTURE_1m7q| PDB=1m7q | SCENE= }}
{{STRUCTURE_1m7q| PDB=1m7q | SCENE= }}
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'''Crystal structure of p38 MAP kinase in complex with a dihydroquinazolinone inhibitor'''
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===Crystal structure of p38 MAP kinase in complex with a dihydroquinazolinone inhibitor===
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==Overview==
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The development of potent, orally bioavailable (in rat) and selective dihydroquinazolinone inhibitors of p38alpha MAP kinase is described. These analogues are hybrids of a pyridinylimidazole p38alpha inhibitor reported by Merck Research Laboratories and VX-745. Optimization of the C-5 phenyl and the C-7 piperidinyl substituents led to the identification of 15i which gave excellent suppression of TNF-alpha production in LPS-stimulated whole blood (IC(50)=10nM) and good oral exposure in rats (F=68%, AUCn PO=0.58 microM h).
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(as it appears on PubMed at http://www.pubmed.gov), where 12482439 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12482439}}
==About this Structure==
==About this Structure==
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[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Serine/threonine kinase]]
[[Category: Serine/threonine kinase]]
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Revision as of 20:23, 2 July 2008

Image:1m7q.png

Template:STRUCTURE 1m7q

Crystal structure of p38 MAP kinase in complex with a dihydroquinazolinone inhibitor

Template:ABSTRACT PUBMED 12482439

About this Structure

1M7Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase., Stelmach JE, Liu L, Patel SB, Pivnichny JV, Scapin G, Singh S, Hop CE, Wang Z, Strauss JR, Cameron PM, Nichols EA, O'Keefe SJ, O'Neill EA, Schmatz DM, Schwartz CD, Thompson CM, Zaller DM, Doherty JB, Bioorg Med Chem Lett. 2003 Jan 20;13(2):277-80. PMID:12482439

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