1m8z

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[[Image:1m8z.gif|left|200px]]
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{{STRUCTURE_1m8z| PDB=1m8z | SCENE= }}
{{STRUCTURE_1m8z| PDB=1m8z | SCENE= }}
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'''Crystal Structure Of A Pumilio-Homology Domain'''
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===Crystal Structure Of A Pumilio-Homology Domain===
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==Overview==
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Puf proteins regulate translation and mRNA stability by binding sequences in their target RNAs through the Pumilio homology domain (PUM-HD), which is characterized by eight tandem copies of a 36 amino acid motif, the PUM repeat. We have solved the structure of the PUM-HD from human Pumilio1 at 1.9 A resolution. The structure reveals that the eight PUM repeats correspond to eight copies of a single, repeated structural motif. The PUM repeats pack together to form a right-handed superhelix that approximates a half doughnut. The distribution of side chains on the inner and outer faces of this half doughnut suggests that the inner face of the PUM-HD binds RNA while the outer face interacts with proteins such as Nanos, Brain Tumor, and cytoplasmic polyadenylation element binding protein.
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(as it appears on PubMed at http://www.pubmed.gov), where 11336708 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11336708}}
==About this Structure==
==About this Structure==
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[[Category: Puf domain]]
[[Category: Puf domain]]
[[Category: Pumilio homology domain]]
[[Category: Pumilio homology domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:46:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:27:58 2008''

Revision as of 20:28, 2 July 2008

Image:1m8z.png

Template:STRUCTURE 1m8z

Crystal Structure Of A Pumilio-Homology Domain

Template:ABSTRACT PUBMED 11336708

About this Structure

1M8Z is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1ib3. Full crystallographic information is available from OCA.

Reference

Crystal structure of a Pumilio homology domain., Wang X, Zamore PD, Hall TM, Mol Cell. 2001 Apr;7(4):855-65. PMID:11336708

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