This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1m9o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1m9o.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1m9o.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1m9o| PDB=1m9o | SCENE= }}
{{STRUCTURE_1m9o| PDB=1m9o | SCENE= }}
-
'''NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11'''
+
===NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11===
-
==Overview==
+
<!--
-
Nup475 (also known as tristetraprolin and TIS11) includes two zinc-binding domains of the form Cys-X8-Cys-X5-Cys-X3-His. These domains are required for rapid degradation of tumor necrosis factor (TNF) and other mRNAs through the interaction with AU-rich elements in their 3'-untranslated regions. The three-dimensional solution structure of the first domain was determined by multidimensional nuclear magnetic resonance spectroscopy, revealing a novel fold around a central zinc ion. The core structure is disk-like with a diameter of approximately 25 A and a width of approximately 12 A. This structure provides a basis for evaluating the role of individual residues for structural stability and for nucleic acid binding.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12515557}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12515557 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12515557}}
==About this Structure==
==About this Structure==
-
1M9O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M9O OCA].
+
1M9O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M9O OCA].
==Reference==
==Reference==
Line 26: Line 30:
[[Category: Worthington, M T.]]
[[Category: Worthington, M T.]]
[[Category: Cys3his type zinc finger]]
[[Category: Cys3his type zinc finger]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:47:58 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:30:28 2008''

Revision as of 20:30, 2 July 2008

Image:1m9o.png

Template:STRUCTURE 1m9o

NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11

Template:ABSTRACT PUBMED 12515557

About this Structure

1M9O is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

A Cys3His zinc-binding domain from Nup475/tristetraprolin: a novel fold with a disklike structure., Amann BT, Worthington MT, Berg JM, Biochemistry. 2003 Jan 14;42(1):217-21. PMID:12515557

Page seeded by OCA on Wed Jul 2 23:30:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1m9o"
Personal tools