1mb8

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[[Image:1mb8.gif|left|200px]]
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{{STRUCTURE_1mb8| PDB=1mb8 | SCENE= }}
{{STRUCTURE_1mb8| PDB=1mb8 | SCENE= }}
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'''Crystal Structure of the actin binding domain of plectin'''
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===Crystal Structure of the actin binding domain of plectin===
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==Overview==
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Plectin is a widely expressed cytoskeletal linker. Here we report the crystal structure of the actin binding domain of plectin and show that this region is sufficient for interaction with F-actin or the cytoplasmic region of integrin alpha6beta4. The structure is formed by two calponin homology domains arranged in a closed conformation. We show that binding to F-actin induces a conformational change in plectin that is inhibited by an engineered interdomain disulfide bridge. A two-step induced fit mechanism involving binding and subsequent domain rearrangement is proposed. In contrast, interaction with integrin alpha6beta4 occurs in a closed conformation. Competitive binding of plectin to F-actin and integrin alpha6beta4 may rely on the observed alternative binding mechanisms and involve both allosteric and steric factors.
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(as it appears on PubMed at http://www.pubmed.gov), where 12791251 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12791251}}
==About this Structure==
==About this Structure==
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[[Category: Epidermolysis bullosa]]
[[Category: Epidermolysis bullosa]]
[[Category: Integrin beta4 hemidesmosome]]
[[Category: Integrin beta4 hemidesmosome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:50:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:36:31 2008''

Revision as of 20:36, 2 July 2008

Image:1mb8.png

Template:STRUCTURE 1mb8

Crystal Structure of the actin binding domain of plectin

Template:ABSTRACT PUBMED 12791251

About this Structure

1MB8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural and functional analysis of the actin binding domain of plectin suggests alternative mechanisms for binding to F-actin and integrin beta4., Garcia-Alvarez B, Bobkov A, Sonnenberg A, de Pereda JM, Structure. 2003 Jun;11(6):615-25. PMID:12791251

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