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1mdg

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{{STRUCTURE_1mdg| PDB=1mdg | SCENE= }}
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'''An Alternating Antiparallel Octaplex in an RNA Crystal Structure'''
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===An Alternating Antiparallel Octaplex in an RNA Crystal Structure===
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==Overview==
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Multistranded helical structures in nucleic acids play various functions in biological processes. Here we report the crystal structure of a hexamer, rU(BrdG)r(AGGU),at 1.5 A resolution containing a structural complex of an alternating antiparallel eight-stranded helical fragment that is sandwiched in two tetraplexes. The octaplex is formed by groove binding interaction and base tetrad intercalation between two tetraplexes. Two different forms of octaplexes have been proposed, which display different properties in interaction with proteins and nucleic acids. Adenines form a base tetrad in the novel N6-H em leader N3 conformation and further interact with uridines to form an adenine-uridine octad in the reverse Hoogsteen pairing scheme. The conformational flexibility of adenine tetrad indicates that it can optimize its conformation in different interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 12842045 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12842045}}
==About this Structure==
==About this Structure==
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[[Category: Rna]]
[[Category: Rna]]
[[Category: Tetraplex]]
[[Category: Tetraplex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:54:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:44:01 2008''

Revision as of 20:44, 2 July 2008

Image:1mdg.png

Template:STRUCTURE 1mdg

An Alternating Antiparallel Octaplex in an RNA Crystal Structure

Template:ABSTRACT PUBMED 12842045

About this Structure

Full crystallographic information is available from OCA.

Reference

An eight-stranded helical fragment in RNA crystal structure: implications for tetraplex interaction., Pan B, Xiong Y, Shi K, Sundaralingam M, Structure. 2003 Jul;11(7):825-31. PMID:12842045

Page seeded by OCA on Wed Jul 2 23:44:01 2008

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