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1me3

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[[Image:1me3.jpg|left|200px]]
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{{STRUCTURE_1me3| PDB=1me3 | SCENE= }}
{{STRUCTURE_1me3| PDB=1me3 | SCENE= }}
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'''High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (II)'''
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===High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (II)===
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==Overview==
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The crystal structures of two hydroxymethyl ketone inhibitors complexed to the cysteine protease cruzain have been determined at 1.1 and 1.2 A resolution, respectively. These high resolution crystal structures provide the first structures of non-covalent inhibitors bound to cruzain. A series of compounds were prepared and tested based upon the structures providing further insight into the key binding interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 12467703 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12467703}}
==About this Structure==
==About this Structure==
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[[Category: Cysteine protease]]
[[Category: Cysteine protease]]
[[Category: Non-covalent inhibitor]]
[[Category: Non-covalent inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:55:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:46:22 2008''

Revision as of 20:46, 2 July 2008

Image:1me3.png

Template:STRUCTURE 1me3

High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (II)

Template:ABSTRACT PUBMED 12467703

About this Structure

1ME3 is a Single protein structure of sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.

Reference

Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain., Huang L, Brinen LS, Ellman JA, Bioorg Med Chem. 2003 Jan 2;11(1):21-9. PMID:12467703

Page seeded by OCA on Wed Jul 2 23:46:22 2008

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