1mf6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1mf6.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1mf6.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1mf6| PDB=1mf6 | SCENE= }}
{{STRUCTURE_1mf6| PDB=1mf6 | SCENE= }}
-
'''Transducin gamma subunit, C-terminal domain 60-71, rhodopsin-bound state: Ensemble of 15 models determined by TrNOE spectroscopy'''
+
===Transducin gamma subunit, C-terminal domain 60-71, rhodopsin-bound state: Ensemble of 15 models determined by TrNOE spectroscopy===
-
==Overview==
+
<!--
-
Rhodopsin, a prototypical G protein-coupled receptor, catalyzes the activation of a heterotrimeric G protein, transducin, to initiate a visual signaling cascade in photoreceptor cells. The betagamma subunit complex, especially the C-terminal domain of the transducin gamma subunit, Gtgamma(60-71)farnesyl, plays a pivotal role in allosteric regulation of nucleotide exchange on the transducin alpha subunit by light-activated rhodopsin. We report that this domain is unstructured in the presence of an inactive receptor but forms an amphipathic helix upon rhodopsin activation. A K65E/E66K charge reversal mutant of the gamma subunit has diminished interactions with the receptor and fails to adopt the helical conformation. The identification of this conformational switch provides a mechanism for active GPCR utilization of the betagamma complex in signal transfer to G proteins.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12679015}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12679015 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12679015}}
==About this Structure==
==About this Structure==
-
1MF6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MF6 OCA].
+
1MF6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MF6 OCA].
==Reference==
==Reference==
Line 30: Line 34:
[[Category: Rhodopsin]]
[[Category: Rhodopsin]]
[[Category: Transducin]]
[[Category: Transducin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:57:45 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:50:13 2008''

Revision as of 20:50, 2 July 2008

Image:1mf6.png

Template:STRUCTURE 1mf6

Transducin gamma subunit, C-terminal domain 60-71, rhodopsin-bound state: Ensemble of 15 models determined by TrNOE spectroscopy

Template:ABSTRACT PUBMED 12679015

About this Structure

1MF6 is a Single protein structure of sequence from Bos taurus. Full experimental information is available from OCA.

Reference

Rhodopsin controls a conformational switch on the transducin gamma subunit., Kisselev OG, Downs MA, Structure. 2003 Apr;11(4):367-73. PMID:12679015

Page seeded by OCA on Wed Jul 2 23:50:13 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mf6"
Personal tools