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1mfq

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[[Image:1mfq.gif|left|200px]]
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{{STRUCTURE_1mfq| PDB=1mfq | SCENE= }}
{{STRUCTURE_1mfq| PDB=1mfq | SCENE= }}
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'''Crystal Structure Analysis of a Ternary S-Domain Complex of Human Signal Recognition Particle'''
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===Crystal Structure Analysis of a Ternary S-Domain Complex of Human Signal Recognition Particle===
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==Overview==
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The eukaryotic signal recognition particle (SRP) is a cytoplasmic ribonucleoprotein particle that targets secretory and membrane proteins to the endoplasmic reticulum. The binding of SRP54 to the S domain of 7SL RNA is highly dependent on SRP19. Here we present the crystal structure of a human SRP ternary complex consisting of SRP19, the M domain of SRP54 and the S domain of 7SL RNA. Upon binding of the M domain of SRP54 to the 7SL RNA-SRP19 complex, the asymmetric loop of helix 8 in 7SL RNA collapses. The bases of the four nucleotides in the long strand of the asymmetric loop continuously stack and interact with the M domain, whereas the two adenines in the short strand flip out and form two A-minor motifs with helix 6. This stabilizing interaction is only possible when helix 6 has been positioned parallel to helix 8 by the prior binding of SRP19 to the tetraloops of helices 6 and 8. Hence, the crystal structure of the ternary complex suggests why SRP19 is necessary for the stable binding of SRP54 to the S domain RNA.
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The line below this paragraph, {{ABSTRACT_PUBMED_12244299}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12244299 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12244299}}
==About this Structure==
==About this Structure==
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[[Category: A-minor motif]]
[[Category: A-minor motif]]
[[Category: Rna-protein complex]]
[[Category: Rna-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:58:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:52:08 2008''

Revision as of 20:52, 2 July 2008

Image:1mfq.png

Template:STRUCTURE 1mfq

Crystal Structure Analysis of a Ternary S-Domain Complex of Human Signal Recognition Particle

Template:ABSTRACT PUBMED 12244299

About this Structure

1MFQ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Induced structural changes of 7SL RNA during the assembly of human signal recognition particle., Kuglstatter A, Oubridge C, Nagai K, Nat Struct Biol. 2002 Oct;9(10):740-4. PMID:12244299

Page seeded by OCA on Wed Jul 2 23:52:08 2008

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