1mh9

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{{STRUCTURE_1mh9| PDB=1mh9 | SCENE= }}
{{STRUCTURE_1mh9| PDB=1mh9 | SCENE= }}
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'''Crystal Structure Analysis of deoxyribonucleotidase'''
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===Crystal Structure Analysis of deoxyribonucleotidase===
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==Overview==
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5' nucleotidases are ubiquitous enzymes that dephosphorylate nucleoside monophosphates and participate in the regulation of nucleotide pools. The mitochondrial 5'-(3') deoxyribonucleotidase (dNT-2) specifically dephosphorylates dUMP and dTMP, thereby protecting mitochondrial DNA replication from excess dTTP. We have solved the structure of dNT-2, the first of a mammalian 5' nucleotidase. The structure reveals a relationship to the HAD family, members of which use an aspartyl nucleophile as their common catalytic strategy, with a phosphoserine phosphatase as the most similar neighbor. A structure-based sequence alignment of dNT-2 with other 5' nucleotidases also suggests a common origin for these enzymes. Here we study the structures of dNT-2 in complex with bound phosphate and beryllium trifluoride plus thymidine as model for a phosphoenzyme-product complex. Based on these structures, determinants for substrate specificity recognition and the catalytic action of dNT-2 are outlined.
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The line below this paragraph, {{ABSTRACT_PUBMED_12352955}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12352955 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12352955}}
==About this Structure==
==About this Structure==
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[[Category: 4-helix bundle]]
[[Category: 4-helix bundle]]
[[Category: Rossman fold]]
[[Category: Rossman fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:00:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:57:41 2008''

Revision as of 20:57, 2 July 2008

Image:1mh9.png

Template:STRUCTURE 1mh9

Crystal Structure Analysis of deoxyribonucleotidase

Template:ABSTRACT PUBMED 12352955

About this Structure

1MH9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a human mitochondrial deoxyribonucleotidase., Rinaldo-Matthis A, Rampazzo C, Reichard P, Bianchi V, Nordlund P, Nat Struct Biol. 2002 Oct;9(10):779-87. PMID:12352955

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