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1miy

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[[Image:1miy.gif|left|200px]]
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{{STRUCTURE_1miy| PDB=1miy | SCENE= }}
{{STRUCTURE_1miy| PDB=1miy | SCENE= }}
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'''Crystal structure of Bacillus stearothermophilus CCA-adding enzyme in complex with CTP'''
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===Crystal structure of Bacillus stearothermophilus CCA-adding enzyme in complex with CTP===
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==Overview==
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CCA-adding enzymes polymerize CCA onto the 3' terminus of immature tRNAs without using a nucleic acid template. The 3.0 A resolution crystal structures of the CCA-adding enzyme from Bacillus stearothermophilus and its complexes with ATP or CTP reveal a seahorse-shaped subunit consisting of four domains: head, neck, body, and tail. The head is structurally homologous to the palm domain of DNA polymerase beta but has additional structural features and functions. The neck, body, and tail represent new protein folding motifs. The neck provides a specific template for the incoming ATP or CTP, whereas the body and tail may bind tRNA. Each subunit has one active site capable of switching its base specificity between ATP and CTP, an important component of the CCA-adding mechanism.
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(as it appears on PubMed at http://www.pubmed.gov), where 12526808 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12526808}}
==About this Structure==
==About this Structure==
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[[Category: Cca-adding enzyme]]
[[Category: Cca-adding enzyme]]
[[Category: Trna nucleotidyltransferase]]
[[Category: Trna nucleotidyltransferase]]
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Revision as of 21:04, 2 July 2008

Image:1miy.png

Template:STRUCTURE 1miy

Crystal structure of Bacillus stearothermophilus CCA-adding enzyme in complex with CTP

Template:ABSTRACT PUBMED 12526808

About this Structure

1MIY is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and its complexes with ATP or CTP., Li F, Xiong Y, Wang J, Cho HD, Tomita K, Weiner AM, Steitz TA, Cell. 2002 Dec 13;111(6):815-24. PMID:12526808

Page seeded by OCA on Thu Jul 3 00:04:33 2008

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