1mq0
From Proteopedia
(New page: 200px<br /> <applet load="1mq0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mq0, resolution 2.40Å" /> '''Crystal Structure o...) |
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| - | [[Image:1mq0.gif|left|200px]]<br /> | + | [[Image:1mq0.gif|left|200px]]<br /><applet load="1mq0" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1mq0" size=" | + | |
caption="1mq0, resolution 2.40Å" /> | caption="1mq0, resolution 2.40Å" /> | ||
'''Crystal Structure of Human Cytidine Deaminase'''<br /> | '''Crystal Structure of Human Cytidine Deaminase'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Human cytidine deaminase (CDA) is an enzyme prominent for its role in | + | Human cytidine deaminase (CDA) is an enzyme prominent for its role in catalyzing metabolic processing of nucleoside-type anticancer and antiviral agents. It is thus a promising target for the development of small molecule therapeutic adjuvants. We report the first crystal structure of human CDA as a complex with a tight-binding inhibitor, diazepinone riboside 1. The structure reveals that inhibitor 1 is able to establish a canonical pi/pi-interaction with a key active site residue, Phe 137. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1MQ0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN and BRD as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cytidine_deaminase Cytidine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.5 3.5.4.5] Full crystallographic information is available from [http:// | + | 1MQ0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=BRD:'>BRD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cytidine_deaminase Cytidine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.5 3.5.4.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQ0 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Chung, S | + | [[Category: Chung, S J.]] |
| - | [[Category: Fromme, J | + | [[Category: Fromme, J C.]] |
| - | [[Category: Verdine, G | + | [[Category: Verdine, G L.]] |
[[Category: BRD]] | [[Category: BRD]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
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[[Category: zinc]] | [[Category: zinc]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:57:47 2008'' |
Revision as of 11:57, 21 February 2008
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Crystal Structure of Human Cytidine Deaminase
Contents |
Overview
Human cytidine deaminase (CDA) is an enzyme prominent for its role in catalyzing metabolic processing of nucleoside-type anticancer and antiviral agents. It is thus a promising target for the development of small molecule therapeutic adjuvants. We report the first crystal structure of human CDA as a complex with a tight-binding inhibitor, diazepinone riboside 1. The structure reveals that inhibitor 1 is able to establish a canonical pi/pi-interaction with a key active site residue, Phe 137.
Disease
Known disease associated with this structure: Anemia, congenital dyserythropoietic, type I OMIM:[607465]
About this Structure
1MQ0 is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Cytidine deaminase, with EC number 3.5.4.5 Full crystallographic information is available from OCA.
Reference
Structure of human cytidine deaminase bound to a potent inhibitor., Chung SJ, Fromme JC, Verdine GL, J Med Chem. 2005 Feb 10;48(3):658-60. PMID:15689149
Page seeded by OCA on Thu Feb 21 13:57:47 2008
Categories: Cytidine deaminase | Homo sapiens | Single protein | Chung, S J. | Fromme, J C. | Verdine, G L. | BRD | ZN | Amine hydrolase | Anticancer | Chemotherapy | Diazepinone | Drug | Edge-to-face interaction | Enzyme | Human | Inhibitor | Leukemia | Phi-phi interaction | Protein | Zinc
