8p72

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'''Unreleased structure'''
 
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The entry 8p72 is ON HOLD until Paper Publication
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==Cryo-EM structure of CAK in complex with inhibitor ICEC0768==
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<StructureSection load='8p72' size='340' side='right'caption='[[8p72]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8p72]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P72 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=X2Z:~{N}7-(phenylmethyl)-~{N}5-[(3~{S})-piperidin-3-yl]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidine-5,7-diamine'>X2Z</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p72 OCA], [https://pdbe.org/8p72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p72 RCSB], [https://www.ebi.ac.uk/pdbsum/8p72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p72 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MAT1_HUMAN MAT1_HUMAN] Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.<ref>PMID:10024882</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ali S]]
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[[Category: Bahl AK]]
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[[Category: Cushing VI]]
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[[Category: Feng J]]
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[[Category: Greber BJ]]
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[[Category: Jurgaityte K]]
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[[Category: Koh AF]]
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[[Category: Kotecha A]]

Revision as of 08:19, 20 March 2024

Cryo-EM structure of CAK in complex with inhibitor ICEC0768

PDB ID 8p72

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