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1mnc

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[[Image:1mnc.gif|left|200px]]
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{{STRUCTURE_1mnc| PDB=1mnc | SCENE= }}
{{STRUCTURE_1mnc| PDB=1mnc | SCENE= }}
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'''STRUCTURE OF HUMAN NEUTROPHIL COLLAGENASE REVEALS LARGE S1' SPECIFICITY POCKET'''
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===STRUCTURE OF HUMAN NEUTROPHIL COLLAGENASE REVEALS LARGE S1' SPECIFICITY POCKET===
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==Overview==
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The crystal structure of the catalytic domain of human neutrophil collagenase complexed with a peptide transition state analogue has been determined to a resolution of 2.1 A. The structure of the neutrophil enzyme, when compared with the three dimensional structure of the corresponding human fibroblast collagenase, shows differences in the first, S1', of the three enzyme specificity subsites on the carboxy-terminal side of the substrate scissile bond. The S1' pocket in the neutrophil collagenase is significantly larger than the equivalent site in the fibroblast enzyme, suggesting that the former enzyme has a broader range of possible substrates. Such differences also suggest approaches for the design of selective matrix metalloproteinase inhibitors.
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(as it appears on PubMed at http://www.pubmed.gov), where 7656015 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7656015}}
==About this Structure==
==About this Structure==
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[[Category: Spurlino, J C.]]
[[Category: Spurlino, J C.]]
[[Category: Stams, T.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:27:22 2008''

Revision as of 21:27, 2 July 2008

Image:1mnc.png

Template:STRUCTURE 1mnc

STRUCTURE OF HUMAN NEUTROPHIL COLLAGENASE REVEALS LARGE S1' SPECIFICITY POCKET

Template:ABSTRACT PUBMED 7656015

About this Structure

1MNC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human neutrophil collagenase reveals large S1' specificity pocket., Stams T, Spurlino JC, Smith DL, Wahl RC, Ho TF, Qoronfleh MW, Banks TM, Rubin B, Nat Struct Biol. 1994 Feb;1(2):119-23. PMID:7656015

Page seeded by OCA on Thu Jul 3 00:27:22 2008

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