1mox

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[[Image:1mox.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1mox| PDB=1mox | SCENE= }}
{{STRUCTURE_1mox| PDB=1mox | SCENE= }}
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'''Crystal Structure of Human Epidermal Growth Factor Receptor (residues 1-501) in complex with TGF-alpha'''
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===Crystal Structure of Human Epidermal Growth Factor Receptor (residues 1-501) in complex with TGF-alpha===
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==Overview==
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We report the crystal structure, at 2.5 A resolution, of a truncated human EGFR ectodomain bound to TGFalpha. TGFalpha interacts with both L1 and L2 domains of EGFR, making many main chain contacts with L1 and interacting with L2 via key conserved residues. The results indicate how EGFR family members can bind a family of highly variable ligands. In the 2:2 TGFalpha:sEGFR501 complex, each ligand interacts with only one receptor molecule. There are two types of dimers in the asymmetric unit: a head-to-head dimer involving contacts between the L1 and L2 domains and a back-to-back dimer dominated by interactions between the CR1 domains of each receptor. Based on sequence conservation, buried surface area, and mutagenesis experiments, the back-to-back dimer is favored to be biologically relevant.
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(as it appears on PubMed at http://www.pubmed.gov), where 12297049 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12297049}}
==Disease==
==Disease==
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[[Category: Growth factor]]
[[Category: Growth factor]]
[[Category: Receptor]]
[[Category: Receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:32:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:37:11 2008''

Revision as of 21:37, 2 July 2008

Image:1mox.png

Template:STRUCTURE 1mox

Contents

Crystal Structure of Human Epidermal Growth Factor Receptor (residues 1-501) in complex with TGF-alpha

Template:ABSTRACT PUBMED 12297049

Disease

Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, susceptibility to OMIM:[131550]

About this Structure

1MOX is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha., Garrett TP, McKern NM, Lou M, Elleman TC, Adams TE, Lovrecz GO, Zhu HJ, Walker F, Frenkel MJ, Hoyne PA, Jorissen RN, Nice EC, Burgess AW, Ward CW, Cell. 2002 Sep 20;110(6):763-73. PMID:12297049

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