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1mpq

From Proteopedia

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[[Image:1mpq.jpg|left|200px]]
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{{STRUCTURE_1mpq| PDB=1mpq | SCENE= }}
{{STRUCTURE_1mpq| PDB=1mpq | SCENE= }}
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'''MALTOPORIN TREHALOSE COMPLEX'''
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===MALTOPORIN TREHALOSE COMPLEX===
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==Overview==
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Maltoporin (LamB) facilitates the diffusion of maltodextrins across the outer membrane of E. coli. The structural basis for the specificity of the channel is investigated by X-ray structure analysis of maltoporin in complex with the disaccharides sucrose, trehalose, and melibiose. The sucrose complex, determined to 2.4 A resolution, shows that the glucosyl moiety is partly inserted into the channel constriction, while the bulky fructosyl residue appears to be hindered to enter the constriction, thus interfering with its further translocation. One of the glucosyl moieties of trehalose is found in a similar position as the glucosyl moiety of sucrose, whereas melibiose appears disordered when bound to maltoporin. A comparison with the previously reported maltoporin-maltose complex sheds light on the basis for sugar discrimination, and explains the different permeation rates observed for the saccharides.
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(as it appears on PubMed at http://www.pubmed.gov), where 9299337 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9299337}}
==About this Structure==
==About this Structure==
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[[Category: Specific porin]]
[[Category: Specific porin]]
[[Category: Sugar transport]]
[[Category: Sugar transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:33:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:43:31 2008''

Revision as of 21:43, 2 July 2008

Image:1mpq.png

Template:STRUCTURE 1mpq

MALTOPORIN TREHALOSE COMPLEX

Template:ABSTRACT PUBMED 9299337

About this Structure

1MPQ is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Channel specificity: structural basis for sugar discrimination and differential flux rates in maltoporin., Wang YF, Dutzler R, Rizkallah PJ, Rosenbusch JP, Schirmer T, J Mol Biol. 1997 Sep 12;272(1):56-63. PMID:9299337

Page seeded by OCA on Thu Jul 3 00:43:31 2008

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