We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1mpv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1mpv.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1mpv.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1mpv| PDB=1mpv | SCENE= }}
{{STRUCTURE_1mpv| PDB=1mpv | SCENE= }}
-
'''Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide'''
+
===Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide===
-
==Overview==
+
<!--
-
The TNF-like ligand BAFF/BLyS is a potent survival factor for B cells. It binds three receptors: TACI, BCMA, and BR3. We show that BR3 signaling promotes processing of the transcription factor NF-kappaB2/p100 to p52. NF-kappaB2/p100 cleavage was abrogated in B cells from A/WySnJ mice possessing a mutant BR3 gene, but not in TACI or BCMA null B cells. Furthermore, wild-type mice injected with BAFF-neutralizing BR3-Fc protein showed reduced basal NF-kappaB2 activation. BR3-Fc treatment of NZB/WF1 mice, which develop a fatal lupus-like syndrome, inhibited NF-kappaB2 processing and attenuated the disease process. Since inhibiting the BR3-BAFF interaction has therapeutic ramifications, the ligand binding interface of BR3 was investigated and found to reside within a 26 residue core domain. When stabilized within a structured beta-hairpin peptide, six of these residues were sufficient to confer binding to BAFF.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12387744}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12387744 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12387744}}
==About this Structure==
==About this Structure==
-
1MPV is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPV OCA].
+
1MPV is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPV OCA].
==Reference==
==Reference==
Line 34: Line 38:
[[Category: Yin, J.]]
[[Category: Yin, J.]]
[[Category: Beta-hairpin]]
[[Category: Beta-hairpin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:34:19 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:45:27 2008''

Revision as of 21:45, 2 July 2008

Image:1mpv.png

Template:STRUCTURE 1mpv

Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide

Template:ABSTRACT PUBMED 12387744

About this Structure

1MPV is a Single protein structure. Full experimental information is available from OCA.

Reference

BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2., Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM, Immunity. 2002 Oct;17(4):515-24. PMID:12387744

Page seeded by OCA on Thu Jul 3 00:45:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mpv"
Personal tools