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1mpx

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[[Image:1mpx.gif|left|200px]]
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{{Seed}}
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[[Image:1mpx.png|left|200px]]
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{{STRUCTURE_1mpx| PDB=1mpx | SCENE= }}
{{STRUCTURE_1mpx| PDB=1mpx | SCENE= }}
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'''ALPHA-AMINO ACID ESTER HYDROLASE LABELED WITH SELENOMETHIONINE'''
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===ALPHA-AMINO ACID ESTER HYDROLASE LABELED WITH SELENOMETHIONINE===
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==Overview==
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alpha-Amino acid ester hydrolases (AEHs) catalyze the hydrolysis and synthesis of esters and amides with an alpha-amino group. As such, they can synthesize beta-lactam antibiotics from acyl compounds and beta-lactam nuclei obtained from the hydrolysis of natural antibiotics. This article describes the gene sequence and the 1.9-A resolution crystal structure of the AEH from Xanthomonas citri. The enzyme consists of an alpha/beta-hydrolase fold domain, a helical cap domain, and a jellyroll beta-domain. Structural homology was observed to the Rhodococcus cocaine esterase, indicating that both enzymes belong to the same class of bacterial hydrolases. Docking of a beta-lactam antibiotic in the active site explains the substrate specificity, specifically the necessity of an alpha-amino group on the substrate, and explains the low specificity toward the beta-lactam nucleus.
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(as it appears on PubMed at http://www.pubmed.gov), where 12684501 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12684501}}
==About this Structure==
==About this Structure==
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[[Category: Jellyroll]]
[[Category: Jellyroll]]
[[Category: Selenomethionine]]
[[Category: Selenomethionine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:34:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:46:53 2008''

Revision as of 21:47, 2 July 2008

Image:1mpx.png

Template:STRUCTURE 1mpx

ALPHA-AMINO ACID ESTER HYDROLASE LABELED WITH SELENOMETHIONINE

Template:ABSTRACT PUBMED 12684501

About this Structure

1MPX is a Single protein structure of sequence from Xanthomonas citri. Full crystallographic information is available from OCA.

Reference

The sequence and crystal structure of the alpha-amino acid ester hydrolase from Xanthomonas citri define a new family of beta-lactam antibiotic acylases., Barends TR, Polderman-Tijmes JJ, Jekel PA, Hensgens CM, de Vries EJ, Janssen DB, Dijkstra BW, J Biol Chem. 2003 Jun 20;278(25):23076-84. Epub 2003 Apr 8. PMID:12684501

Page seeded by OCA on Thu Jul 3 00:46:53 2008

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