1mpx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1mpx.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1mpx.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1mpx| PDB=1mpx | SCENE= }}
{{STRUCTURE_1mpx| PDB=1mpx | SCENE= }}
-
'''ALPHA-AMINO ACID ESTER HYDROLASE LABELED WITH SELENOMETHIONINE'''
+
===ALPHA-AMINO ACID ESTER HYDROLASE LABELED WITH SELENOMETHIONINE===
-
==Overview==
+
<!--
-
alpha-Amino acid ester hydrolases (AEHs) catalyze the hydrolysis and synthesis of esters and amides with an alpha-amino group. As such, they can synthesize beta-lactam antibiotics from acyl compounds and beta-lactam nuclei obtained from the hydrolysis of natural antibiotics. This article describes the gene sequence and the 1.9-A resolution crystal structure of the AEH from Xanthomonas citri. The enzyme consists of an alpha/beta-hydrolase fold domain, a helical cap domain, and a jellyroll beta-domain. Structural homology was observed to the Rhodococcus cocaine esterase, indicating that both enzymes belong to the same class of bacterial hydrolases. Docking of a beta-lactam antibiotic in the active site explains the substrate specificity, specifically the necessity of an alpha-amino group on the substrate, and explains the low specificity toward the beta-lactam nucleus.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12684501}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12684501 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12684501}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Jellyroll]]
[[Category: Jellyroll]]
[[Category: Selenomethionine]]
[[Category: Selenomethionine]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:34:37 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:46:53 2008''

Revision as of 21:47, 2 July 2008

Image:1mpx.png

Template:STRUCTURE 1mpx

ALPHA-AMINO ACID ESTER HYDROLASE LABELED WITH SELENOMETHIONINE

Template:ABSTRACT PUBMED 12684501

About this Structure

1MPX is a Single protein structure of sequence from Xanthomonas citri. Full crystallographic information is available from OCA.

Reference

The sequence and crystal structure of the alpha-amino acid ester hydrolase from Xanthomonas citri define a new family of beta-lactam antibiotic acylases., Barends TR, Polderman-Tijmes JJ, Jekel PA, Hensgens CM, de Vries EJ, Janssen DB, Dijkstra BW, J Biol Chem. 2003 Jun 20;278(25):23076-84. Epub 2003 Apr 8. PMID:12684501

Page seeded by OCA on Thu Jul 3 00:46:53 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mpx"
Personal tools