1mq0

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[[Image:1mq0.gif|left|200px]]
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{{STRUCTURE_1mq0| PDB=1mq0 | SCENE= }}
{{STRUCTURE_1mq0| PDB=1mq0 | SCENE= }}
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'''Crystal Structure of Human Cytidine Deaminase'''
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===Crystal Structure of Human Cytidine Deaminase===
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==Overview==
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Human cytidine deaminase (CDA) is an enzyme prominent for its role in catalyzing metabolic processing of nucleoside-type anticancer and antiviral agents. It is thus a promising target for the development of small molecule therapeutic adjuvants. We report the first crystal structure of human CDA as a complex with a tight-binding inhibitor, diazepinone riboside 1. The structure reveals that inhibitor 1 is able to establish a canonical pi/pi-interaction with a key active site residue, Phe 137.
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The line below this paragraph, {{ABSTRACT_PUBMED_15689149}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15689149 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15689149}}
==About this Structure==
==About this Structure==
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[[Category: Protein]]
[[Category: Protein]]
[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:34:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:47:25 2008''

Revision as of 21:47, 2 July 2008

Image:1mq0.png

Template:STRUCTURE 1mq0

Crystal Structure of Human Cytidine Deaminase

Template:ABSTRACT PUBMED 15689149

About this Structure

1MQ0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human cytidine deaminase bound to a potent inhibitor., Chung SJ, Fromme JC, Verdine GL, J Med Chem. 2005 Feb 10;48(3):658-60. PMID:15689149

Page seeded by OCA on Thu Jul 3 00:47:25 2008

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