This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1mzc
From Proteopedia
(New page: 200px<br /> <applet load="1mzc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mzc, resolution 2.00Å" /> '''Co-Crystal Structur...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1mzc. | + | [[Image:1mzc.jpg|left|200px]]<br /><applet load="1mzc" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1mzc" size=" | + | |
caption="1mzc, resolution 2.00Å" /> | caption="1mzc, resolution 2.00Å" /> | ||
'''Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a'''<br /> | '''Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a'''<br /> | ||
| Line 8: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1MZC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SUC, ZN, FPP and BNE as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1MZC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SUC:'>SUC</scene>, <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=FPP:'>FPP</scene> and <scene name='pdbligand=BNE:'>BNE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MZC OCA]. |
==Reference== | ==Reference== | ||
| Line 43: | Line 42: | ||
[[Category: ras]] | [[Category: ras]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:26:13 2008'' |
Revision as of 14:26, 15 February 2008
|
Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a
Overview
A series of novel diaryl ether lactams have been identified as very potent, dual inhibitors of protein farnesyltransferase (FTase) and protein, geranylgeranyltransferase I (GGTase-I), enzymes involved in the, prenylation of Ras. The structure of the complex formed between one of, these compounds and FTase has been determined by X-ray crystallography., These compounds are the first reported to inhibit the prenylation of the, important oncogene Ki-Ras4B in vivo. Unfortunately, doses sufficient to, achieve this endpoint were rapidly lethal.
About this Structure
1MZC is a Protein complex structure of sequences from Homo sapiens with , , and as ligands. Full crystallographic information is available from OCA.
Reference
Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents., deSolms SJ, Ciccarone TM, MacTough SC, Shaw AW, Buser CA, Ellis-Hutchings M, Fernandes C, Hamilton KA, Huber HE, Kohl NE, Lobell RB, Robinson RG, Tsou NN, Walsh ES, Graham SL, Beese LS, Taylor JS, J Med Chem. 2003 Jul 3;46(14):2973-84. PMID:12825937
Page seeded by OCA on Fri Feb 15 16:26:13 2008
Categories: Homo sapiens | Protein complex | Beese, L.S. | Buser, C.A. | Ciccarone, T.M. | Ellis-Hutchings, M. | Fernandes, C. | Graham, S.L. | Hamilton, K.A. | Huber, H.E. | Kohl, N.E. | Lobell, R.B. | MacTough, S.C. | Robinson, R.G. | Shaw, A.W. | Taylor, J.S. | Tsou, N.N. | Walsh, E.S. | DeSolms, S.J. | BNE | FPP | SUC | ZN | Alpha-alpha barrel | Caax | Fpp | Ftase | Inhibitor | Pftase | Ras
