1n1m

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(New page: 200px<br /> <applet load="1n1m" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n1m, resolution 2.50&Aring;" /> '''Human Dipeptidyl Pe...)
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[[Image:1n1m.gif|left|200px]]<br />
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<applet load="1n1m" size="450" color="white" frame="true" align="right" spinBox="true"
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caption="1n1m, resolution 2.50&Aring;" />
caption="1n1m, resolution 2.50&Aring;" />
'''Human Dipeptidyl Peptidase IV/CD26 in complex with an inhibitor'''<br />
'''Human Dipeptidyl Peptidase IV/CD26 in complex with an inhibitor'''<br />
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==About this Structure==
==About this Structure==
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1N1M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG, HG and A3M as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1N1M OCA].
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1N1M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=HG:'>HG</scene> and <scene name='pdbligand=A3M:'>A3M</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1M OCA].
==Reference==
==Reference==
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[[Category: dimer]]
[[Category: dimer]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 18:16:55 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:26:36 2008''

Revision as of 14:26, 15 February 2008

Image:1n1m.jpg

1n1m, resolution 2.50Å

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Human Dipeptidyl Peptidase IV/CD26 in complex with an inhibitor

Overview

Dipeptidyl peptidase IV (DPP-IV/CD26) is a multifunctional type II, transmembrane serine peptidase. This enzyme contributes to the regulation, of various physiological processes, including blood sugar homeostasis, by, cleaving peptide hormones, chemokines and neuropeptides. We have, determined the 2.5 A structure of the extracellular region of DPP-IV in, complex with the inhibitor valine-pyrrolidide. The catalytic site is, located in a large cavity formed between the alpha/beta-hydrolase domain, and an eight-bladed beta-propeller domain. Both domains participate in, inhibitor binding. The structure indicates how substrate specificity is, achieved and reveals a new and unexpected opening to the active site.

About this Structure

1N1M is a Single protein structure of sequence from Homo sapiens with , and as ligands. Active as Dipeptidyl-peptidase IV, with EC number 3.4.14.5 Full crystallographic information is available from OCA.

Reference

Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog., Rasmussen HB, Branner S, Wiberg FC, Wagtmann N, Nat Struct Biol. 2003 Jan;10(1):19-25. PMID:12483204

Page seeded by OCA on Fri Feb 15 16:26:36 2008

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