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1n26
From Proteopedia
(New page: 200px<br /> <applet load="1n26" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n26, resolution 2.4Å" /> '''Crystal Structure of...) |
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| - | [[Image:1n26.gif|left|200px]]<br /> | + | [[Image:1n26.gif|left|200px]]<br /><applet load="1n26" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1n26" size=" | + | |
caption="1n26, resolution 2.4Å" /> | caption="1n26, resolution 2.4Å" /> | ||
'''Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain'''<br /> | '''Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Dysregulated production of IL-6 and its receptor (IL-6R) are implicated in | + | Dysregulated production of IL-6 and its receptor (IL-6R) are implicated in the pathogenesis of multiple myeloma, autoimmune diseases and prostate cancer. The IL-6R complex comprises two molecules each of IL-6, IL-6R, and the signaling molecule, gp130. Here, we report the x-ray structure (2.4 A) of the IL-6R ectodomains. The N-terminal strand of the Ig-like domain (D(1)) is disulfide-bonded to domain D(2), and domains D(2) and D(3), the cytokine-binding domain, are structurally similar to known cytokine-binding domains. The head-to-tail packing of two closely associated IL-6R molecules observed in the crystal may be representative of the configuration of the physiological dimer of IL-6R and provides new insight into the architecture of the IL-6R complex. |
==About this Structure== | ==About this Structure== | ||
| - | 1N26 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG, SO4 and CYS as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1N26 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=CYS:'>CYS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N26 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Branson, K | + | [[Category: Branson, K M.]] |
| - | [[Category: Donkelaar, A | + | [[Category: Donkelaar, A van.]] |
| - | [[Category: Hall, N | + | [[Category: Hall, N E.]] |
[[Category: Ivancic, N.]] | [[Category: Ivancic, N.]] | ||
[[Category: Ji, H.]] | [[Category: Ji, H.]] | ||
| - | [[Category: Lou, M | + | [[Category: Lou, M Z.]] |
| - | [[Category: Moritz, R | + | [[Category: Moritz, R L.]] |
| - | [[Category: Simpson, R | + | [[Category: Simpson, R J.]] |
| - | [[Category: Varghese, J | + | [[Category: Varghese, J N.]] |
[[Category: CYS]] | [[Category: CYS]] | ||
[[Category: NAG]] | [[Category: NAG]] | ||
| Line 30: | Line 29: | ||
[[Category: transmembrane]] | [[Category: transmembrane]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:01:29 2008'' |
Revision as of 12:01, 21 February 2008
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Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain
Overview
Dysregulated production of IL-6 and its receptor (IL-6R) are implicated in the pathogenesis of multiple myeloma, autoimmune diseases and prostate cancer. The IL-6R complex comprises two molecules each of IL-6, IL-6R, and the signaling molecule, gp130. Here, we report the x-ray structure (2.4 A) of the IL-6R ectodomains. The N-terminal strand of the Ig-like domain (D(1)) is disulfide-bonded to domain D(2), and domains D(2) and D(3), the cytokine-binding domain, are structurally similar to known cytokine-binding domains. The head-to-tail packing of two closely associated IL-6R molecules observed in the crystal may be representative of the configuration of the physiological dimer of IL-6R and provides new insight into the architecture of the IL-6R complex.
About this Structure
1N26 is a Single protein structure of sequence from Homo sapiens with , and as ligands. Full crystallographic information is available from OCA.
Reference
Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain., Varghese JN, Moritz RL, Lou MZ, Van Donkelaar A, Ji H, Ivancic N, Branson KM, Hall NE, Simpson RJ, Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15959-64. Epub 2002 Dec 2. PMID:12461182
Page seeded by OCA on Thu Feb 21 14:01:29 2008
Categories: Homo sapiens | Single protein | Branson, K M. | Donkelaar, A van. | Hall, N E. | Ivancic, N. | Ji, H. | Lou, M Z. | Moritz, R L. | Simpson, R J. | Varghese, J N. | CYS | NAG | SO4 | Glycoprotein | Immunoglobulin domain | Transmembrane
