1mst

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{{STRUCTURE_1mst| PDB=1mst | SCENE= }}
{{STRUCTURE_1mst| PDB=1mst | SCENE= }}
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'''CRYSTAL STRUCTURE OF MS2 CAPSIDS WITH MUTATIONS IN THE SUBUNIT FG LOOP'''
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===CRYSTAL STRUCTURE OF MS2 CAPSIDS WITH MUTATIONS IN THE SUBUNIT FG LOOP===
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==Overview==
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The loop between the F and G beta strands (FG loop) of the bacteriophage MS2 coat protein subunit forms inter-subunit contacts around the 5-fold and 3-fold (quasi 6-fold) axes of the T=3 protein shell. In capsids, the loop is found in two very different conformations, one in B subunits, which form the 5-fold contact, and one in A and C subunits, which form the quasi 6-fold contact. One proline residue, Pro78, is strictly conserved in the coat protein of all related bacteriophages, and in the case of MS2 this proline residue is preceded by a cis peptide bond in the B subunit. In order to probe the role of the FG loop in capsid assembly, we have determined the crystal structures of two MS2 capsids, formed by coat proteins with mutations at two positions in the FG loop, P78N or E76D. These mutants show conformational changes in the FG loops that explain the reduced temperature stability of the capsids. The P78N mutant has a normal trans peptide bond at position 78.
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{{ABSTRACT_PUBMED_8594200}}
==About this Structure==
==About this Structure==
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[[Category: Bacteriophage coat protein]]
[[Category: Bacteriophage coat protein]]
[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:18:25 2008''

Revision as of 10:18, 29 July 2008

Image:1mst.png

Template:STRUCTURE 1mst

CRYSTAL STRUCTURE OF MS2 CAPSIDS WITH MUTATIONS IN THE SUBUNIT FG LOOP

Template:ABSTRACT PUBMED 8594200

About this Structure

1MST is a Single protein structure of sequence from Enterobacterio phage ms2. Full crystallographic information is available from OCA.

Reference

Crystal structures of MS2 capsids with mutations in the subunit FG loop., Stonehouse NJ, Valegard K, Golmohammadi R, van den Worm S, Walton C, Stockley PG, Liljas L, J Mol Biol. 1996 Feb 23;256(2):330-9. PMID:8594200

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