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1msz

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[[Image:1msz.gif|left|200px]]
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{{STRUCTURE_1msz| PDB=1msz | SCENE= }}
{{STRUCTURE_1msz| PDB=1msz | SCENE= }}
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'''Solution structure of the R3H domain from human Smubp-2'''
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===Solution structure of the R3H domain from human Smubp-2===
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==Overview==
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The R3H domain is a conserved sequence motif, identified in over 100 proteins, that is thought to be involved in polynucleotide-binding, including DNA, RNA and single-stranded DNA. In this work the 3D structure of the R3H domain from human Smubp-2 was determined by NMR spectroscopy. It is the first 3D structure determination of an R3H domain. The fold presents a small motif, consisting of a three-stranded antiparallel beta-sheet and two alpha-helices, which is related to the structures of the YhhP protein and the C-terminal domain of the translational initiation factor IF3. The similarities are non-trivial, as the amino acid identities are below 10%. Three conserved basic residues cluster on the same face of the R3H domain and could play a role in nucleic acid recognition. An extended hydrophobic area at a different site of the molecular surface could act as a protein-binding site. A strong correlation between conservation of hydrophobic amino acids and side-chain solvent protection indicates that the structure of the Smubp-2 R3H domain is representative of R3H domains in general.
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(as it appears on PubMed at http://www.pubmed.gov), where 12547203 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12547203}}
==About this Structure==
==About this Structure==
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1MSZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MSZ OCA].
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1MSZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MSZ OCA].
==Reference==
==Reference==
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[[Category: Sharipo, A.]]
[[Category: Sharipo, A.]]
[[Category: R3h fold]]
[[Category: R3h fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:40:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:21:19 2008''

Revision as of 09:21, 28 July 2008

Image:1msz.png

Template:STRUCTURE 1msz

Solution structure of the R3H domain from human Smubp-2

Template:ABSTRACT PUBMED 12547203

About this Structure

1MSZ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the R3H domain from human Smubp-2., Liepinsh E, Leonchiks A, Sharipo A, Guignard L, Otting G, J Mol Biol. 2003 Feb 7;326(1):217-23. PMID:12547203

Page seeded by OCA on Mon Jul 28 12:21:19 2008

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