This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1msz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1msz.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1msz.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1msz| PDB=1msz | SCENE= }}
{{STRUCTURE_1msz| PDB=1msz | SCENE= }}
-
'''Solution structure of the R3H domain from human Smubp-2'''
+
===Solution structure of the R3H domain from human Smubp-2===
-
==Overview==
+
<!--
-
The R3H domain is a conserved sequence motif, identified in over 100 proteins, that is thought to be involved in polynucleotide-binding, including DNA, RNA and single-stranded DNA. In this work the 3D structure of the R3H domain from human Smubp-2 was determined by NMR spectroscopy. It is the first 3D structure determination of an R3H domain. The fold presents a small motif, consisting of a three-stranded antiparallel beta-sheet and two alpha-helices, which is related to the structures of the YhhP protein and the C-terminal domain of the translational initiation factor IF3. The similarities are non-trivial, as the amino acid identities are below 10%. Three conserved basic residues cluster on the same face of the R3H domain and could play a role in nucleic acid recognition. An extended hydrophobic area at a different site of the molecular surface could act as a protein-binding site. A strong correlation between conservation of hydrophobic amino acids and side-chain solvent protection indicates that the structure of the Smubp-2 R3H domain is representative of R3H domains in general.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12547203}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12547203 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12547203}}
==About this Structure==
==About this Structure==
-
1MSZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MSZ OCA].
+
1MSZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MSZ OCA].
==Reference==
==Reference==
Line 28: Line 32:
[[Category: Sharipo, A.]]
[[Category: Sharipo, A.]]
[[Category: R3h fold]]
[[Category: R3h fold]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:40:58 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:21:19 2008''

Revision as of 09:21, 28 July 2008

Image:1msz.png

Template:STRUCTURE 1msz

Solution structure of the R3H domain from human Smubp-2

Template:ABSTRACT PUBMED 12547203

About this Structure

1MSZ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the R3H domain from human Smubp-2., Liepinsh E, Leonchiks A, Sharipo A, Guignard L, Otting G, J Mol Biol. 2003 Feb 7;326(1):217-23. PMID:12547203

Page seeded by OCA on Mon Jul 28 12:21:19 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1msz"
Personal tools