1mt6

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{{STRUCTURE_1mt6| PDB=1mt6 | SCENE= }}
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'''Structure of histone H3 K4-specific methyltransferase SET7/9 with AdoHcy'''
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===Structure of histone H3 K4-specific methyltransferase SET7/9 with AdoHcy===
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==Overview==
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The SET domain contains the catalytic center of lysine methyltransferases that target the N-terminal tails of histones and regulate chromatin function. Here we report the structure of the SET7/9 protein in the absence and presence of its cofactor product, S-adenosyl-L-homocysteine (AdoHcy). A knot within the SET domain helps form the methyltransferase active site, where AdoHcy binds and lysine methylation is likely to occur. A structure-guided comparison of sequences within the SET protein family suggests that the knot substructure and active site environment are conserved features of the SET domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 12389038 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12389038}}
==About this Structure==
==About this Structure==
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[[Category: Knot]]
[[Category: Knot]]
[[Category: Set domain]]
[[Category: Set domain]]
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Revision as of 11:19, 27 July 2008

Image:1mt6.png

Template:STRUCTURE 1mt6

Structure of histone H3 K4-specific methyltransferase SET7/9 with AdoHcy

Template:ABSTRACT PUBMED 12389038

About this Structure

1MT6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The active site of the SET domain is constructed on a knot., Jacobs SA, Harp JM, Devarakonda S, Kim Y, Rastinejad F, Khorasanizadeh S, Nat Struct Biol. 2002 Nov;9(11):833-8. PMID:12389038

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