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1mtz

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{{STRUCTURE_1mtz| PDB=1mtz | SCENE= }}
{{STRUCTURE_1mtz| PDB=1mtz | SCENE= }}
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'''Crystal Structure of the Tricorn Interacting Factor F1'''
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===Crystal Structure of the Tricorn Interacting Factor F1===
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==Overview==
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F1 is a 33.5 kDa serine peptidase of the alpha/beta-hydrolase family from the archaeon Thermoplasma acidophilum. Subsequent to proteasomal protein degradation, tricorn generates small peptides, which are cleaved by F1 to yield single amino acids. We have solved the crystal structure of F1 with multiwavelength anomalous dispersion (MAD) phasing at 1.8 A resolution. In addition to the conserved catalytic domain, the structure reveals a chiefly alpha-helical domain capping the catalytic triad. Thus, the active site is accessible only through a narrow opening from the protein surface. Two structures with molecules bound to the active serine, including the inhibitor phenylalanyl chloromethylketone, elucidate the N-terminal recognition of substrates and the catalytic activation switch mechanism of F1. The cap domain mainly confers the specificity for hydrophobic side chains by a novel cavity system, which, analogously to the tricorn protease, guides substrates to the buried active site and products away from it. Finally, the structure of F1 suggests a possible functional complex with tricorn that allows efficient processive degradation to free amino acids for cellular recycling.
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(as it appears on PubMed at http://www.pubmed.gov), where 12374735 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12374735}}
==About this Structure==
==About this Structure==
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[[Category: Cap domain]]
[[Category: Cap domain]]
[[Category: Prolyl peptidase]]
[[Category: Prolyl peptidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:42:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:57:36 2008''

Revision as of 13:57, 28 July 2008

Image:1mtz.png

Template:STRUCTURE 1mtz

Crystal Structure of the Tricorn Interacting Factor F1

Template:ABSTRACT PUBMED 12374735

About this Structure

1MTZ is a Single protein structure of sequence from Thermoplasma acidophilum. Full crystallographic information is available from OCA.

Reference

Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism., Goettig P, Groll M, Kim JS, Huber R, Brandstetter H, EMBO J. 2002 Oct 15;21(20):5343-52. PMID:12374735

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