This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1mug

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1mug.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1mug.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1mug| PDB=1mug | SCENE= }}
{{STRUCTURE_1mug| PDB=1mug | SCENE= }}
-
'''G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI'''
+
===G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI===
-
==Overview==
+
<!--
-
G:U mismatches resulting from deamination of cytosine are the most common promutagenic lesions occurring in DNA. Uracil is removed in a base-excision repair pathway by uracil DNA-glycosylase (UDG), which excises uracil from both single- and double-stranded DNA. Recently, a biochemically distinct family of DNA repair enzymes has been identified, which excises both uracil and thymine, but only from mispairs with guanine. Crystal structures of the mismatch-specific uracil DNA-glycosylase (MUG) from E. coli, and of a DNA complex, reveal a remarkable structural and functional homology to UDGs despite low sequence identity. Details of the MUG structure explain its thymine DNA-glycosylase activity and the specificity for G:U/T mispairs, which derives from direct recognition of guanine on the complementary strand.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9489705}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9489705 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9489705}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Savva, R.]]
[[Category: Savva, R.]]
[[Category: Dna-glycosylase]]
[[Category: Dna-glycosylase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:43:46 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:43:51 2008''

Revision as of 14:43, 28 July 2008

Image:1mug.png

Template:STRUCTURE 1mug

G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI

Template:ABSTRACT PUBMED 9489705

About this Structure

1MUG is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions., Barrett TE, Savva R, Panayotou G, Barlow T, Brown T, Jiricny J, Pearl LH, Cell. 1998 Jan 9;92(1):117-29. PMID:9489705

Page seeded by OCA on Mon Jul 28 17:43:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mug"
Personal tools