8tzr

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Current revision (14:13, 18 October 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8tzr is ON HOLD until Paper Publication
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==Structure of human Wnt3a bound to WLS and CALR==
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<StructureSection load='8tzr' size='340' side='right'caption='[[8tzr]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8tzr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TZR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TZR FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tzr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tzr OCA], [https://pdbe.org/8tzr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tzr RCSB], [https://www.ebi.ac.uk/pdbsum/8tzr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tzr ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/WNT3A_HUMAN WNT3A_HUMAN] Idiopathic juvenile osteoporosis.
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== Function ==
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[https://www.uniprot.org/uniprot/WNT3A_HUMAN WNT3A_HUMAN] Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20093360, PubMed:21244856, PubMed:24841207, PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720).[UniProtKB:P27467]<ref>PMID:20093360</ref> <ref>PMID:21244856</ref> <ref>PMID:24841207</ref> <ref>PMID:26902720</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Hu Q]]
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[[Category: Li X]]
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[[Category: Qi X]]

Current revision

Structure of human Wnt3a bound to WLS and CALR

PDB ID 8tzr

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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