1mup

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{{STRUCTURE_1mup| PDB=1mup | SCENE= }}
{{STRUCTURE_1mup| PDB=1mup | SCENE= }}
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'''PHEROMONE BINDING TO TWO RODENT URINARY PROTEINS REVEALED BY X-RAY CRYSTALLOGRAPHY'''
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===PHEROMONE BINDING TO TWO RODENT URINARY PROTEINS REVEALED BY X-RAY CRYSTALLOGRAPHY===
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==Overview==
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The principal protein excreted in male rat urine, urinary alpha 2-globulin and the homologous mouse protein, major urinary protein, have been well characterized, although their functions remain unclear. Male rat urine affects the behaviour and sexual response of female rats, leading to the proposal that rodent urinary proteins are responsible for binding pheromones and their subsequent release from drying urine. Urinary alpha 2-globulin is also involved in hyaline droplet nephropathy, an important toxicological syndrome in male rats resulting from exposure to a number of industrial chemicals and characterized by the accumulation of liganded urinary alpha 2-globulin in lysosomes in the kidney, followed by the induction of renal cancer. We now report the three-dimensional structures of mouse major urinary protein (at 2.4 A resolution) and rat urinary alpha 2-globulin (at 2.8 A resolution). The results corroborate the role of these proteins in pheromone transport and elaborate the structural basis of ligand binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 1279439 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1279439}}
==About this Structure==
==About this Structure==
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[[Category: Phillips, S E.V.]]
[[Category: Phillips, S E.V.]]
[[Category: Pheromone-binding]]
[[Category: Pheromone-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:44:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:48:42 2008''

Revision as of 05:48, 29 July 2008

Image:1mup.png

Template:STRUCTURE 1mup

PHEROMONE BINDING TO TWO RODENT URINARY PROTEINS REVEALED BY X-RAY CRYSTALLOGRAPHY

Template:ABSTRACT PUBMED 1279439

About this Structure

1MUP is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography., Bocskei Z, Groom CR, Flower DR, Wright CE, Phillips SE, Cavaggioni A, Findlay JB, North AC, Nature. 1992 Nov 12;360(6400):186-8. PMID:1279439

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