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1mw4

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[[Image:1mw4.jpg|left|200px]]
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{{STRUCTURE_1mw4| PDB=1mw4 | SCENE= }}
{{STRUCTURE_1mw4| PDB=1mw4 | SCENE= }}
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'''Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139'''
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===Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139===
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==Overview==
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The solution structure of the hGrb7-SH2 domain in complex with a ten amino acid phosphorylated peptide ligand representative of the erbB2 receptor tyrosine kinase (pY1139) is presented as determined by nuclear magnetic resonance methods. The hGrb7-SH2 domain structure reveals the Src homology 2 domain topology consisting of a central beta-sheet capped at each end by an alpha-helix. The presence of a four residue insertion in the region between beta-strand E and the EF loop and resulting influences on the SH2 domain/peptide complex structure are discussed. The binding conformation of the erbB2 peptide is in a beta-turn similar to that found in phosphorylated tyrosine peptides bound to the Grb2-SH2 domain. To our knowledge this is only the second example of an SH2 domain binding its naturally occurring ligands in a turn, instead of extended, conformation. Close contacts between residues responsible for binding specificity in hGrb7-SH2 and the erbB2 peptide are characterized and the potential effect of mutation of these residues on the hGrb7-SH2 domain structure is discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_12975581}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12975581 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12975581}}
==About this Structure==
==About this Structure==
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1MW4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MW4 OCA].
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1MW4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MW4 OCA].
==Reference==
==Reference==
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[[Category: Lyons, B A.]]
[[Category: Lyons, B A.]]
[[Category: Sh2 domain in complex with a ligand]]
[[Category: Sh2 domain in complex with a ligand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:47:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:32:11 2008''

Revision as of 07:32, 28 July 2008

Image:1mw4.png

Template:STRUCTURE 1mw4

Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139

Template:ABSTRACT PUBMED 12975581

About this Structure

1MW4 is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2., Ivancic M, Daly RJ, Lyons BA, J Biomol NMR. 2003 Nov;27(3):205-19. PMID:12975581

Page seeded by OCA on Mon Jul 28 10:32:11 2008

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