This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1mw9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1mw9.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1mw9.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1mw9| PDB=1mw9 | SCENE= }}
{{STRUCTURE_1mw9| PDB=1mw9 | SCENE= }}
-
'''Crystal Structure of H365R mutant of 67 kDA N-terminal fragment of E. coli DNA Topoisomerase I'''
+
===Crystal Structure of H365R mutant of 67 kDA N-terminal fragment of E. coli DNA Topoisomerase I===
-
==Overview==
+
<!--
-
In order to gain insights into the mechaism of ssDNA binding and recognition by Escherichia coli DNA topoisomerase I, the structure of the 67 kDa N-terminal fragment of topoisomerase I was solved in complex with ssDNA. The structure reveals a new conformational stage in the multistep catalytic cycle of type IA topoisomerases. In the structure, the ssDNA binding groove leading to the active site is occupied, but the active site is not fully formed. Large conformational changes are not seen; instead, a single helix parallel to the ssDNA binding groove shifts to clamp the ssDNA. The structure helps clarify the temporal sequence of conformational events, starting from an initial empty enzyme and proceeding to a ssDNA-occupied and catalytically competent active site.
+
The line below this paragraph, {{ABSTRACT_PUBMED_14604525}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 14604525 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_14604525}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Dna topoisomerase]]
[[Category: Dna topoisomerase]]
[[Category: Toprim domain]]
[[Category: Toprim domain]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:47:42 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:10:38 2008''

Revision as of 13:10, 29 July 2008

Image:1mw9.png

Template:STRUCTURE 1mw9

Crystal Structure of H365R mutant of 67 kDA N-terminal fragment of E. coli DNA Topoisomerase I

Template:ABSTRACT PUBMED 14604525

About this Structure

1MW9 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of a complex between E. coli DNA topoisomerase I and single-stranded DNA., Perry K, Mondragon A, Structure. 2003 Nov;11(11):1349-58. PMID:14604525

Page seeded by OCA on Tue Jul 29 16:10:38 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mw9"
Personal tools