1mwb

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[[Image:1mwb.jpg|left|200px]]
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[[Image:1mwb.png|left|200px]]
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{{STRUCTURE_1mwb| PDB=1mwb | SCENE= }}
{{STRUCTURE_1mwb| PDB=1mwb | SCENE= }}
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'''Solution structure of the recombinant hemoglobin from the cyanobacterium Synechocystis sp. PCC 6803 in its hemichrome state'''
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===Solution structure of the recombinant hemoglobin from the cyanobacterium Synechocystis sp. PCC 6803 in its hemichrome state===
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==Overview==
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The product of the cyanobacterium Synechocystis sp. PCC 6803 gene slr2097 is a 123 amino acid polypeptide chain belonging to the truncated hemoglobin family. Recombinant, ferric heme-reconstituted Synechocystis sp. PCC 6803 hemoglobin displays bis-histidine coordination of the iron ion. In addition, this protein is capable of covalently attaching a reactive histidine to the heme 2-vinyl group. The structure of the protein in the low-spin ferric state with intact vinyl substituents was solved by NMR methods. It was found that the structure differs from that of known truncated hemoglobins primarily in the orientation of the E helix, which carries His46 (E10) as the distal ligand to the iron; the length and orientation of the F helix, which carries His70 (F8) as the proximal ligand to the iron; and the H-helix, which carries His117 (H16), the reactive histidine. Regions of enhanced flexibility include the short A helix, the loop connecting the E and F helices, and the last seven residues at the carboxy end. The structural data allowed for the rationalization of physical properties of the cyanobacterial protein, such as fast on-rate for small ligand binding, unstable apoprotein fold, and cross-linking ability. Comparison to the truncated hemoglobin from the green alga Chlamydomonas eugametos also suggested how the endogenous hexacoordination affected the structure.
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{{ABSTRACT_PUBMED_12470956}}
==About this Structure==
==About this Structure==
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1MWB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MWB OCA].
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1MWB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MWB OCA].
==Reference==
==Reference==
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[[Category: Cyanoglobin]]
[[Category: Cyanoglobin]]
[[Category: Globin]]
[[Category: Globin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:47:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:31:21 2008''

Revision as of 10:33, 28 July 2008

Image:1mwb.png

Template:STRUCTURE 1mwb

Solution structure of the recombinant hemoglobin from the cyanobacterium Synechocystis sp. PCC 6803 in its hemichrome state

Template:ABSTRACT PUBMED 12470956

About this Structure

1MWB is a Single protein structure of sequence from Synechocystis sp.. Full experimental information is available from OCA.

Reference

The solution structure of the recombinant hemoglobin from the cyanobacterium Synechocystis sp. PCC 6803 in its hemichrome state., Falzone CJ, Christie Vu B, Scott NL, Lecomte JT, J Mol Biol. 2002 Dec 13;324(5):1015-29. PMID:12470956

Page seeded by OCA on Mon Jul 28 13:31:21 2008

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