1mwr

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[[Image:1mwr.gif|left|200px]]
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{{STRUCTURE_1mwr| PDB=1mwr | SCENE= }}
{{STRUCTURE_1mwr| PDB=1mwr | SCENE= }}
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'''Structure of SeMet Penicillin binding protein 2a from methicillin resistant Staphylococcus aureus strain 27r (trigonal form) at 2.45 A resolution.'''
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===Structure of SeMet Penicillin binding protein 2a from methicillin resistant Staphylococcus aureus strain 27r (trigonal form) at 2.45 A resolution.===
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==Overview==
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The multiple antibiotic resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) has become a major clinical problem worldwide. The key determinant of the broad-spectrum beta-lactam resistance in MRSA strains is the penicillin-binding protein 2a (PBP2a). Because of its low affinity for beta-lactams, PBP2a provides transpeptidase activity to allow cell wall synthesis at beta-lactam concentrations that inhibit the beta-lactam-sensitive PBPs normally produced by S. aureus. The crystal structure of a soluble derivative of PBP2a has been determined to 1.8 A resolution and provides the highest resolution structure for a high molecular mass PBP. Additionally, structures of the acyl-PBP complexes of PBP2a with nitrocefin, penicillin G and methicillin allow, for the first time, a comparison of an apo and acylated resistant PBP. An analysis of the PBP2a active site in these forms reveals the structural basis of its resistance and identifies features in newly developed beta-lactams that are likely important for high affinity binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 12389036 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12389036}}
==About this Structure==
==About this Structure==
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[[Category: D,d-transpeptidase]]
[[Category: D,d-transpeptidase]]
[[Category: Penicillin binding protein]]
[[Category: Penicillin binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:48:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:18:01 2008''

Revision as of 01:18, 28 July 2008

Image:1mwr.png

Template:STRUCTURE 1mwr

Structure of SeMet Penicillin binding protein 2a from methicillin resistant Staphylococcus aureus strain 27r (trigonal form) at 2.45 A resolution.

Template:ABSTRACT PUBMED 12389036

About this Structure

1MWR is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus., Lim D, Strynadka NC, Nat Struct Biol. 2002 Nov;9(11):870-6. PMID:12389036

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