1na7
From Proteopedia
(New page: 200px<br /> <applet load="1na7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1na7, resolution 2.40Å" /> '''Crystal structure o...) |
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| - | [[Image:1na7.gif|left|200px]]<br /> | + | [[Image:1na7.gif|left|200px]]<br /><applet load="1na7" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1na7, resolution 2.40Å" /> | caption="1na7, resolution 2.40Å" /> | ||
'''Crystal structure of the catalytic subunit of human protein kinase CK2'''<br /> | '''Crystal structure of the catalytic subunit of human protein kinase CK2'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The three-dimensional crystal structure of the triple-point mutant of the | + | The three-dimensional crystal structure of the triple-point mutant of the catalytic subunit of human protein kinase CK2alpha has been determined at 2.4 A resolution. Microcrystals of mutant CK2 catalytic subunit were obtained by a protein-crystallization method based on thin-film nanotechnology. These microcrystals (of about 20 micro m in diameter) were used for diffraction data collection by means of the microfocus beamline at the ESRF synchrotron. A comparison between the human protein kinase CK2alpha and the corresponding enzyme from a lower organism (Zea mays) is made. |
==About this Structure== | ==About this Structure== | ||
| - | 1NA7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http:// | + | 1NA7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NA7 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: thin-film nanotechnology]] | [[Category: thin-film nanotechnology]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:03:56 2008'' |
Revision as of 12:03, 21 February 2008
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Crystal structure of the catalytic subunit of human protein kinase CK2
Overview
The three-dimensional crystal structure of the triple-point mutant of the catalytic subunit of human protein kinase CK2alpha has been determined at 2.4 A resolution. Microcrystals of mutant CK2 catalytic subunit were obtained by a protein-crystallization method based on thin-film nanotechnology. These microcrystals (of about 20 micro m in diameter) were used for diffraction data collection by means of the microfocus beamline at the ESRF synchrotron. A comparison between the human protein kinase CK2alpha and the corresponding enzyme from a lower organism (Zea mays) is made.
About this Structure
1NA7 is a Single protein structure of sequence from Homo sapiens. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Full crystallographic information is available from OCA.
Reference
Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2., Pechkova E, Zanotti G, Nicolini C, Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2133-9. Epub 2003, Nov 27. PMID:14646071
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