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1myq

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{{STRUCTURE_1myq| PDB=1myq | SCENE= }}
{{STRUCTURE_1myq| PDB=1myq | SCENE= }}
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'''An intramolecular quadruplex of (GGA)(4) triplet repeat DNA with a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad, and its dimeric interaction'''
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===An intramolecular quadruplex of (GGA)(4) triplet repeat DNA with a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad, and its dimeric interaction===
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==Overview==
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The structure of d(GGAGGAGGAGGA) containing four tandem repeats of a GGA triplet sequence has been determined under physiological K(+) conditions. d(GGAGGAGGAGGA) folds into an intramolecular quadruplex composed of a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad. Four G-G segments of d(GGAGGAGGAGGA) are aligned parallel with each other due to six successive turns of the main chain at each of the GGA and GAGG segments. Two quadruplexes form a dimer stabilized through a stacking interaction between the heptads of the two quadruplexes. Comparison of the structure of d(GGAGGAGGAGGA) with the reported structure of d(GGAGGAN) (N=G or T) containing two tandem repeats of the GGA triplet revealed that although the two structures resemble each other to some extent, the extension of the repeats of the GGA triplet leads to distinct structural differences: intramolecular quadruplex for 12-mer versus intermolecular quadruplex for 7-mer; heptad versus hexad in the quadruplex; and three sheared G:A base-pairs versus two sheared G:A base-pairs plus one A:A base-pair per quadruplex. It was also suggested that d(GGAGGAGGAGGA) forms a similar quadruplex under low salt concentration conditions. This is in contrast to the case of d(GGAGGAN) (N=G or T), which forms a duplex under low salt concentration conditions. On the basis of these results, the structure of naturally occurring GGA triplet repeat DNA is discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_11800555}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11800555 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11800555}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYQ OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYQ OCA].
==Reference==
==Reference==
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[[Category: Dimeric structure]]
[[Category: Dimeric structure]]
[[Category: Intramolecular parallel quadruplex structure]]
[[Category: Intramolecular parallel quadruplex structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:52:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:48:10 2008''

Revision as of 10:48, 28 July 2008

Image:1myq.png

Template:STRUCTURE 1myq

An intramolecular quadruplex of (GGA)(4) triplet repeat DNA with a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad, and its dimeric interaction

Template:ABSTRACT PUBMED 11800555

About this Structure

Full experimental information is available from OCA.

Reference

An intramolecular quadruplex of (GGA)(4) triplet repeat DNA with a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad, and its dimeric interaction., Matsugami A, Ouhashi K, Kanagawa M, Liu H, Kanagawa S, Uesugi S, Katahira M, J Mol Biol. 2001 Oct 19;313(2):255-69. PMID:11800555

Page seeded by OCA on Mon Jul 28 13:48:10 2008

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