1mzj

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{{STRUCTURE_1mzj| PDB=1mzj | SCENE= }}
{{STRUCTURE_1mzj| PDB=1mzj | SCENE= }}
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'''Crystal Structure of the Priming beta-Ketosynthase from the R1128 Polyketide Biosynthetic Pathway'''
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===Crystal Structure of the Priming beta-Ketosynthase from the R1128 Polyketide Biosynthetic Pathway===
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==Overview==
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ZhuH is a priming ketosynthase that initiates the elongation of the polyketide chain in the biosynthetic pathway of a type II polyketide, R1128. The crystal structure of ZhuH in complex with the priming substrate acetyl-CoA reveals an extensive loop region at the dimer interface that appears to affect the selectivity for the primer unit. Acetyl-CoA is bound in a 20 A-long channel, which placed the acetyl group against the catalytic triad. Analysis of the primer unit binding site in ZhuH suggests that it can accommodate acyl chains that are two to four carbons long. Selectivity and primer unit size appear to involve the side chains of three residues on the loops close to the dimer interface that constitute the bottom of the substrate binding pocket.
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(as it appears on PubMed at http://www.pubmed.gov), where 12429097 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12429097}}
==About this Structure==
==About this Structure==
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[[Category: Biosynthetic engineering]]
[[Category: Biosynthetic engineering]]
[[Category: Catalytic triad]]
[[Category: Catalytic triad]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:54:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:12:38 2008''

Revision as of 23:12, 27 July 2008

Image:1mzj.png

Template:STRUCTURE 1mzj

Crystal Structure of the Priming beta-Ketosynthase from the R1128 Polyketide Biosynthetic Pathway

Template:ABSTRACT PUBMED 12429097

About this Structure

1MZJ is a Single protein structure of sequence from Streptomyces sp. r1128. Full crystallographic information is available from OCA.

Reference

Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway., Pan H, Tsai S, Meadows ES, Miercke LJ, Keatinge-Clay AT, O'Connell J, Khosla C, Stroud RM, Structure. 2002 Nov;10(11):1559-68. PMID:12429097

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