1n03

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{{STRUCTURE_1n03| PDB=1n03 | SCENE= }}
{{STRUCTURE_1n03| PDB=1n03 | SCENE= }}
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'''Model for Active RecA Filament'''
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===Model for Active RecA Filament===
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==Overview==
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The crystal structure of the E. coli RecA protein was solved more than 10 years ago, but it has provided limited insight into the mechanism of homologous genetic recombination. Using electron microscopy, we have reconstructed five different states of RecA-DNA filaments. The C-terminal lobe of the RecA protein is modulated by the state of the distantly bound nucleotide, and this allosteric coupling can explain how mutations and truncations of this C-terminal lobe enhance RecA's activity. A model generated from these reconstructions shows that the nucleotide binding core is substantially rotated from its position in the RecA crystal filament, resulting in ATP binding between subunits. This simple rotation can explain the large cooperativity in ATP hydrolysis observed for RecA-DNA filaments.
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(as it appears on PubMed at http://www.pubmed.gov), where 12575938 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12575938}}
==About this Structure==
==About this Structure==
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[[Category: Yu, X.]]
[[Category: Yu, X.]]
[[Category: Helical polymer]]
[[Category: Helical polymer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:55:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:40:09 2008''

Revision as of 06:40, 28 July 2008

Image:1n03.png

Template:STRUCTURE 1n03

Model for Active RecA Filament

Template:ABSTRACT PUBMED 12575938

About this Structure

1N03 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

ATP-mediated conformational changes in the RecA filament., VanLoock MS, Yu X, Yang S, Lai AL, Low C, Campbell MJ, Egelman EH, Structure. 2003 Feb;11(2):187-96. PMID:12575938

Page seeded by OCA on Mon Jul 28 09:40:09 2008

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