8qlq

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m (Protected "8qlq" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8qlq is ON HOLD
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==Human MST3 (STK24) kinase in complex with macrocyclic inhibitor JA310==
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<StructureSection load='8qlq' size='340' side='right'caption='[[8qlq]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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Authors: Balourdas, D.I., Amrhein, J.A., Hanke, T., Knapp, S., Joerger, A.C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8qlq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QLQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QLQ FirstGlance]. <br>
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Description: Human MST3 (STK24) kinase in complex with macrocyclic inhibitor JA310
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=VY0:macrocyclic+inhibitor'>VY0</scene></td></tr>
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[[Category: Joerger, A.C]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qlq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qlq OCA], [https://pdbe.org/8qlq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qlq RCSB], [https://www.ebi.ac.uk/pdbsum/8qlq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qlq ProSAT]</span></td></tr>
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[[Category: Amrhein, J.A]]
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</table>
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[[Category: Knapp, S]]
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== Function ==
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[[Category: Hanke, T]]
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[https://www.uniprot.org/uniprot/STK24_HUMAN STK24_HUMAN] Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.<ref>PMID:16314523</ref> <ref>PMID:17046825</ref> <ref>PMID:19604147</ref> <ref>PMID:19855390</ref> <ref>PMID:19782762</ref>
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[[Category: Balourdas, D.I]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Amrhein JA]]
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[[Category: Balourdas DI]]
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[[Category: Hanke T]]
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[[Category: Joerger AC]]
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[[Category: Knapp S]]

Revision as of 12:04, 8 November 2023

Human MST3 (STK24) kinase in complex with macrocyclic inhibitor JA310

PDB ID 8qlq

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