8tka
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Orthoreovirus RNA Chaperone SigmaNS R6A mutant== | |
| - | + | <StructureSection load='8tka' size='340' side='right'caption='[[8tka]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8tka]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mammalian_orthoreovirus_1 Mammalian orthoreovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TKA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | [[Category: Hu | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tka OCA], [https://pdbe.org/8tka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tka RCSB], [https://www.ebi.ac.uk/pdbsum/8tka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tka ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [https://www.uniprot.org/uniprot/SIGNS_REOVD SIGNS_REOVD] Protein that binds to ssRNA and participates with protein mu-NS in forming the matrix of viral factories, which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place (PubMed:11152519). Plays a role in the inhibition of the integrated stress response (ISR) to escape from host cell translational shutoff (PubMed:28794026). Participates in the disruption of stress granules (SG) through its association with host G3BP1 and mu-NS (PubMed:28794026).<ref>PMID:11152519</ref> <ref>PMID:28794026</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mammalian orthoreovirus 1]] | ||
| + | [[Category: Hu L]] | ||
| + | [[Category: Prasad BVV]] | ||
| + | [[Category: Zhao B]] | ||
Revision as of 12:10, 6 March 2024
Structure of Orthoreovirus RNA Chaperone SigmaNS R6A mutant
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