1n26

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[[Image:1n26.gif|left|200px]]
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{{Seed}}
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[[Image:1n26.png|left|200px]]
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{{STRUCTURE_1n26| PDB=1n26 | SCENE= }}
{{STRUCTURE_1n26| PDB=1n26 | SCENE= }}
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'''Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain'''
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===Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain===
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==Overview==
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Dysregulated production of IL-6 and its receptor (IL-6R) are implicated in the pathogenesis of multiple myeloma, autoimmune diseases and prostate cancer. The IL-6R complex comprises two molecules each of IL-6, IL-6R, and the signaling molecule, gp130. Here, we report the x-ray structure (2.4 A) of the IL-6R ectodomains. The N-terminal strand of the Ig-like domain (D(1)) is disulfide-bonded to domain D(2), and domains D(2) and D(3), the cytokine-binding domain, are structurally similar to known cytokine-binding domains. The head-to-tail packing of two closely associated IL-6R molecules observed in the crystal may be representative of the configuration of the physiological dimer of IL-6R and provides new insight into the architecture of the IL-6R complex.
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(as it appears on PubMed at http://www.pubmed.gov), where 12461182 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12461182}}
==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin domain]]
[[Category: Immunoglobulin domain]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:59:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:41:10 2008''

Revision as of 21:41, 28 July 2008

Template:STRUCTURE 1n26

Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain

Template:ABSTRACT PUBMED 12461182

About this Structure

1N26 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain., Varghese JN, Moritz RL, Lou MZ, Van Donkelaar A, Ji H, Ivancic N, Branson KM, Hall NE, Simpson RJ, Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15959-64. Epub 2002 Dec 2. PMID:12461182

Page seeded by OCA on Tue Jul 29 00:41:10 2008

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